1-ACETYLINDOLINE Chemical Properties

Melting point:

102-104 °C(lit.)

Boiling point:

125-130 °C(Press: 1 Torr)

Density 

1.144±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

1.13±0.20(Predicted)

CAS DataBase Reference

16078-30-1(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

RTECS 

NM1892500

HS Code 

2933998090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1-ACETYLINDOLINE Usage And Synthesis

Uses

• ;Reactant for preparation of triazolothiadiazepine dioxide derivatives1• ;Reactant for preparation of halo-substituted aromatic amides2• ;Reactant for preparation of [[(phenyl)piperazinyl]alkyl]indolyl]ethanone and [[[(phenoxyethyl)piperazinyl]alkyl]indolyl]ethanone derivatives as α1-adrenoreceptor antagonists3• ;Reactant for synthesis of naphthalenedione derivatives as antimycobacterial agents4• ;Reactant for regioselective ortho Suzuki-Miyaura coupling reaction5

Uses

1-(2,3-Dihydroindol-1-yl)ethanone is an intermediate used for preparation of triazolothiadiazepine dioxide derivatives, halo-substituted aromatic amides and [[(phenyl)piperazinyl]alkyl]indolyl]ethanone.

Uses

• Reactant for preparation of triazolothiadiazepine dioxide derivatives
• Reactant for preparation of halo-substituted aromatic amides
• Reactant for preparation of [[(phenyl)piperazinyl]alkyl]indolyl]ethanone and [[[(phenoxyethyl)piperazinyl]alkyl]indolyl]ethanone derivatives as α1-adrenoreceptor antagonists
• Reactant for synthesis of naphthalenedione derivatives as antimycobacterial agents
• Reactant for regioselective ortho Suzuki-Miyaura coupling reaction

Synthesis Reference(s)

Tetrahedron, 52, p. 7525, 1996 DOI: 10.1016/0040-4020(96)00266-9
Tetrahedron Letters, 24, p. 561, 1983 DOI: 10.1016/S0040-4039(00)81464-1

General Description

1-Acetylindoline, a substituted indole, is a tertiary amide having bulky N-groups. Its reduction to the corresponding amine, by reaction with silane in the presence of MoO₂Cl₂ (catalyst), has been reported.

1-ACETYLINDOLINE(16078-30-1)Related Product Information

• Indoline
• N-ACETYLINDOLE-3-CARBOXALDEHYDE
• 1-ACETYL-5-BROMOINDOLINE
• STRYCHNINE
• 1-ACETYL-5-AMINO-2,3-DIHYDRO-(1H)-INDOLE
• STRYCHNINE
• 10,11-Dimethoxystrychnine
• BRUCINE SULFATE
• Strychnine Nitrate
• 1-ACETYL-6-AMINOINDOLINE
• STRYCHNINE HYDROCHLORIDE
• 1-ACETYL-5-BROMO-7-NITROINDOLINE
• 1-ACETYLINDOLINE
• 1-ACETYL-5-NITROINDOLINE
• BRUCINE HYDROCHLORIDE
• 1-acetylindoline-2,3-dione
• STRYCHNINE-N-OXIDE
• 1-ACETYL-6-CHLOROINDOLINE