5-METHOXY-2-METHYL-3-INDOLEACETIC ACID Chemical Properties

Melting point:

161-163 °C (lit.)

Boiling point:

360.05°C (rough estimate)

Density 

1.1825 (rough estimate)

refractive index 

1.5270 (estimate)

storage temp. 

2-8°C

solubility 

methanol: soluble

pka

4.22±0.30(Predicted)

form 

Crystalline Powder

color 

Off-white to light yellow or light beige

CAS DataBase Reference

2882-15-7(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29349990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

5-METHOXY-2-METHYL-3-INDOLEACETIC ACID Usage And Synthesis

Chemical Properties

slightly yellow fine crystalline powder

Uses

• Reactant for preparation of antimalarial agents
• Reactant for preparation of ndomethacin analogs as cyclooxygenase and lipoxygenase inhibitors with antiinflammatory activity
• Reactant for preparation of [123I]-indomethacin derivatives as COX-2 targeted imaging agents
• Reactant for preparation of histone deacetylase inhibitors
• Reactant for preparation of 2,N6,5′-substituted adenosine derivatives as ligands for A2B adenosine receptor
• Reactant for preparation of prostaglandin D2 receptor antagonist

Uses

5-Methoxy-2-methyl-3-indoleacetic acid was used for quantitative determination of indomethacin and its major impurities in suppository and capsule formulations by HPLC. 5-Methoxy-2-methyl-3-indoleacetic acid was used in a study to develop fast, sensitive and simultaneous determination of metabolites of serotonin using liquid chromatography with mass spectrometric detection.

Uses

A metabolite of Indomethacin.

Definition

ChEBI: N-Deschlorobenzoyl indomethacin is a member of indole-3-acetic acids.

General Description

5-Methoxy-2-methyl-3-indoleacetic acid is hydrolysis product of indomethacin.

5-METHOXY-2-METHYL-3-INDOLEACETIC ACID(2882-15-7)Related Product Information

• 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
• 2-Methylindole
• 4-Chloro-N-(4-Methoxyphenyl)benzaMide, 97%
• 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-hydroxypropyl ester
• 4-Chloro-2-(4-chlorobenzoyl)-1-(4-Methoxyphenyl)hydrazide Benzoic Acid
• 4-Chlorobenzoic acid
• Benzoic acid, 4-chloro-, 2,3-dihydroxypropyl ester
• 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-, ethyl ester
• 1H-INDOLE-3-ACETICACID,1-(3-CHLOROBENZOYL)-5-METHOXY-2-METHYL
• 2-(4-METHOXYPHENYL)HYDRAZINESULFONIC ACID SODIUM SALT MONOHYDRATE
• IndoMethacin DiaMide
• methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate
• 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-,2,3-d ihydroxypropyl ester
• Indometacin EP Impurity G
• Indometacin EP Impurity D
• Indometacin Impurity 17
• Methanone, (4-chlorophenyl)[2,6-dichloro-4-(hydroxymethyl)phenyl]-
• Indometacin Impurity 18