2-[2-(Dimethylamino)ethoxy]ethanol Chemical Properties

Boiling point:

95 °C15 mm Hg(lit.)

Density 

0.954 g/mL at 25 °C(lit.)

vapor pressure 

11Pa at 20℃

refractive index 

n20/D 1.442(lit.)

Flash point:

199 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

clear liquid

pka

14.37±0.10(Predicted)

color 

Colorless to Light yellow to Light orange

Water Solubility 

1000g/L at 20℃

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents, acids, isocyanates.

LogP

-0.778 at 20℃

CAS DataBase Reference

1704-62-7(CAS DataBase Reference)

NIST Chemistry Reference

ethanol, 2-[2-(dimethylamino)ethoxy]-(1704-62-7)

EPA Substance Registry System

Ethanol, 2-[2-(dimethylamino)ethoxy]- (1704-62-7)

Safety Information

Hazard Codes 

Xn

Risk Statements 

21-41

Safety Statements 

26-36/37/39

RIDADR 

NA 1993 / PGIII

WGK Germany 

1

RTECS 

KK6825000

HS Code 

29225090

Toxicity

rabbit,LD50,skin,1410uL/kg (1.41mL/kg),Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974.

MSDS

• Language:English Provider:SigmaAldrich

2-[2-(Dimethylamino)ethoxy]ethanol Usage And Synthesis

Chemical Properties

liquid

Uses

Used for the preparation of low-density packaging foams.

Flammability and Explosibility

Not classified

Synthesis

1. Synthesis step: 63.1 g of diethylene glycolamine (0.6 mol) and 34.5 g of paraformaldehyde (1.2 mol) were added to a 250 mL three-necked flask and stirred for 30 minutes. Subsequently, 63 g of formic acid (1.2 mol, 88%) was added slowly and dropwise. The reaction mixture was heated to 100-110°C and kept at this temperature for 1 hour. Upon completion of the reaction, 30 g of the fraction was distilled under reduced pressure (vacuum -0.094 MPa, kettle temperature 80°C). At this time, the content of the product 2-[2-(dimethylamino)ethoxy]ethanol was 90.0% and the content of impurity (S-2) was 9.8%. 2. Purification step: the above reaction solution was transferred to a 500 mL distillation flask and distilled under reduced pressure (-0.094 MPa). Firstly, the fraction at 62°C was collected, which was mainly n-butanol ester exchange product and butyl formate. Subsequently, the fraction at 121 °C, the target product 2-[2-(dimethylamino)ethoxy]ethanol, was collected, and a total of 128.3 g was obtained in 96.5% yield and 99.9% product purity.

References

[1] Patent: CN106748831, 2017, A. Location in patent: Paragraph 0043-0058; 0064

2-[2-(Dimethylamino)ethoxy]ethanol(1704-62-7)Related Product Information

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