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NICOTINIC ACID HYDRAZIDE

Basic information Safety Supplier Related

NICOTINIC ACID HYDRAZIDE Basic information

Product Name:
NICOTINIC ACID HYDRAZIDE
Synonyms:
  • Isoniazid Impurity B
  • LABOTEST-BB LT01593663
  • (3-pyridylcarbonyl)hydrazine
  • 3-Pyridinecarboxylic acid, hydrazide
  • 3-Pyridinecarboxylic hydrazide
  • 3-pyridinecarboxylicacid,hydrazide
  • 3-Pyridoyl Hydrazine
  • 3-pyridoylhydrazine
CAS:
553-53-7
MF:
C6H7N3O
MW:
137.14
EINECS:
209-041-0
Product Categories:
  • Amines, Aromatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
  • Amines
  • Aromatics
  • Impurities
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • AMIDE
  • Heterocyclic Compounds
Mol File:
553-53-7.mol
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NICOTINIC ACID HYDRAZIDE Chemical Properties

Melting point:
159-161 °C(lit.)
Boiling point:
251.97°C (rough estimate)
Density 
1.2620 (rough estimate)
refractive index 
1.6910 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
H2O: soluble50mg/mL
form 
Fine Needle-Like Crystalline Powder
pka
11.43±0.10(Predicted)
color 
White to off-white
Water Solubility 
Soluble in alcohol, water.
BRN 
119299
InChIKey
KFUSANSHCADHNJ-UHFFFAOYSA-N
CAS DataBase Reference
553-53-7(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-26-36/37/39
RIDADR 
UN2811
WGK Germany 
3
RTECS 
QT1750000
HazardClass 
6.1
PackingGroup 
III
HS Code 
29280000
Toxicity
LD50 intravenous in mouse: 180mg/kg

MSDS

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NICOTINIC ACID HYDRAZIDE Usage And Synthesis

Chemical Properties

WHITE TO OFF-WHITE FINE NEEDLE-LIKE CRYST. POWDER

Uses

Nicotinic hydrazide was used in hydrazone library formation. It was used to study the oxidation of isonicotinic acid hydrazide (isoniazid) by horseradish peroxidase.

Uses

An Impurity of Isoniazid (I821450), potent antitubercular agent against M. tuberculosis.

Biochem/physiol Actions

Nicotinic hydrazide is an inhibitor of peroxidase enzyme. It forms solid metal complexes having strong biological activity.

Purification Methods

Crystallise it from aqueous EtOH or *benzene. [Beilstein 22 III/IV 439, 22/2 V 121.]

NICOTINIC ACID HYDRAZIDE Preparation Products And Raw materials

Raw materials

NICOTINIC ACID HYDRAZIDESupplier

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