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Calcium folinatc
Calcium folinatc Basic information
- Product Name:
- Calcium folinatc
- Synonyms:
-
- calcium 2-[[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]phenyl]-oxomethyl]amino]pentanedioate pentahydrate
- FOLINIC ACID CALCIUM CELL CULTURE TESTED
- Folinic acid, calcium salt pentahydrate, 95.0-105.0%
- Calcium folinatc
- Folinic acid calcium salt
- Leucovorin calcium pentahydrate
- NSC-3590
- CALCIUM FOLINATE(FOLINIC ACID)(RG)
- CAS:
- 6035-45-6
- MF:
- C20H27CaN7O8
- MW:
- 533.56
- Product Categories:
-
- API
- Chiral Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Calcium, Calcium Folinatc, Citrovorum Factor
- Miscellaneous Biochemicals
- Mol File:
- 6035-45-6.mol
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Calcium folinatc Chemical Properties
- Melting point:
- 240-250°C
- alpha
- D21 +14.9° (c = 1 in water)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- insoluble in DMSO; insoluble in EtOH; ≥15.04 mg/mL in H2O with gentle warming
- form
- powder
- color
- Yellow-white to yellow
- InChIKey
- QUCDGUZWVVGQDO-WJYQJPTCNA-N
- SMILES
- C(N1C(CNC2NC(N)=NC(=O)C1=2)CNC1C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=1)=O.[Ca].O |&1:22,r|
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Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-42/43
- Safety Statements
- 26-36
- WGK Germany
- 3
- HS Code
- 29362900
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Calcium folinatc Usage And Synthesis
Chemical Properties
yellowish-white to yellow powder
Uses
An intermediate product of the metabolism of Folic Acid. This compound is a mixture of diastereomers.
Uses
Antianemic
brand name
Wellcovorin (GlaxoSmithKline).
Biological Activity
human lymphoid cell lines were studied for leucovorin requirements to protect from methotrexate (mtx)-induced growth suppression. over a 72h continuous exposure leucovorin provided better protection to the cell lines laz-007 and raji than to the cell line
in vivo
Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2].
| Animal Model: | 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2] |
| Dosage: | 7.0 mg/kg |
| Administration: | Intraperitoneal injection; every second day; for 3 weeks |
| Result: | Following methotrexate (MTX) administration appears to reverse this growth inhibition. |
IC 50
Human Endogenous Metabolite
Calcium folinatc Supplier
Panjin Jiahe Shengshi Pharmaceutical Technology Co., Ltd Gold
- Tel
- 13464671885 13032431717
- sale@jhssw.com
Wuhan penglei Biotechnology Co., Ltd Gold
- Tel
- 15871464247 17307245989
- 3471278124@qq.com
J & K SCIENTIFIC LTD.
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
Chemsky（shanghai）International Co.,Ltd.
- Tel
- 021-50135380
- shchemsky@sina.com
China Langchem Inc.
- Tel
- 0086-21-58956006
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Calcium folinatc (6035-45-6)Related Product Information
- AMINOACETONITRILE HYDROGEN SULFATE
- Calcium formate
- Calcium citrate
- Calcium Propionate
- Folinic acid
- Calcium chloride
- Triamterene
- N,N-Dimethyl-1,4-phenylenediamine
- Calcium cyanamide
- Methyl tetrahydrophthalic anhydride
- Tetramethylammonium hydroxide
- Methylhexahydrophthalic anhydride
- Sodium selenite pentahydrate
- Tris(hydroxymethyl)aminomethane
- Calcium carbonate
- CALCIUM
- Calcium levofolinate
- Calcium folinate
- Folinic Acid Calcium Salt