2-(AMINOMETHYL)BENZIMIDAZOLE DIHYDRO- Chemical Properties

Melting point:

264 °C (dec.)(lit.)

storage temp. 

Inert atmosphere,Room Temperature

form 

solid

Appearance

Off-white to light brown Solid

BRN 

3698942

InChI

InChI=1S/C8H9N3.2ClH.H2O/c9-5-8-10-6-3-1-2-4-7(6)11-8;;;/h1-4H,5,9H2,(H,10,11);2*1H;1H2

InChIKey

HAEYZZSSSUIZAN-UHFFFAOYSA-N

SMILES

C12C=CC=CC=1N=C(CN)N2.O.Cl.Cl

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

Storage Class

11 - Combustible Solids

2-(AMINOMETHYL)BENZIMIDAZOLE DIHYDRO- Usage And Synthesis

Chemical Properties

off-white to green-greyish powder

Uses

2-(Aminomethyl)benzimidazole dihydrochloride was used in the synthesis of N-(benzimidazol-2-ylmethyl)iminodiacetic acid.

Synthesis

A) Take o-phenylenediamine, glycine and 5~6mol/L HCl, sequentially added to the flask, in which the molar ratio of o-phenylenediamine and glycine is 1:1-3, 1:1.5-2.5; the molar ratio of o-phenylenediamine and 5~6mol/LHCl is 1:10-12. stirred uniformly, put into the microwave oven of the frequency of 2450MHz at an output power of 119W and irradiated intermittently for 6 times, 1min each time, to make the total solution.

B) the whole solution in the microwave oven at an output power of 119 ~ 280W intermittent irradiation 10 times, each time the irradiation of 4 ~  6min after an interval of 10min. cooling, precipitation of solids, filtration, anhydrous ethanol washed, drying to obtain the crude product.

C)The crude product was recrystallized with anhydrous ethanol to obtain 2-aminomethylbenzimidazole dihydrochloride, which was dissolved in water, adjusted pH to 8~9 with ammonia, cooled to 3~5 to make the crystallization complete, and recrystallized with ethanol/water to obtain 2-aminomethylbenzimidazole, with a maximum yield of 77%. 2-aminomethylbenzimidazole further reacted with hydrochloric acid to form 2-(aminomethyl)benzimidazole dihydrochloride

2-(AMINOMETHYL)BENZIMIDAZOLE DIHYDRO-(5993-91-9)Related Product Information

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