SOYASAPOGENOL B(P)
SOYASAPOGENOL B(P) Basic information
- Product Name:
- SOYASAPOGENOL B(P)
- Synonyms:
-
- Soyasapogel B
- Soyasapogenol M2
- Soyasapogenol B, 98%, from Glycine max (L.) Merr.
- SOYASAPOGENOL B(P)
- (4S)-Olean-12-ene-3β,22β,24-triol
- Sapogenol B
- (3S,4S,4aR,6aR,6bS,8aR,9R,12aS,14aR,14bR)-4-(hydroxymethyl)-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-3,9-diol
- (3S,4S,4aR,6aR,6bS,8aR,9R,12aS,14aR,14bR)-4,6a,6b,8a,11,11,14b-heptamethyl-4-methylol-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-3,9-diol
- CAS:
- 595-15-3
- MF:
- C30H50O3
- MW:
- 458.72
- Product Categories:
-
- Sapogenins
- Mol File:
- 595-15-3.mol
SOYASAPOGENOL B(P) Chemical Properties
- Melting point:
- 258～259℃
- Boiling point:
- 555.5±50.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 14.91±0.70(Predicted)
- color
- White to off-white
- InChIKey
- YOQAQNKGFOLRGT-ZIPOINFQNA-N
- SMILES
- [C@@]12(C)CC[C@@]3([H])[C@@](C)(CO)[C@@H](O)CC[C@]3(C)[C@@]1([H])CC=C1[C@]3([H])CC(C[C@@H](O)[C@]3(C)CC[C@@]21C)(C)C |&1:0,4,6,10,14,16,21,26,28,32,r|
SOYASAPOGENOL B(P) Usage And Synthesis
Uses
Soyasapogenol B has been shown to attenuate lipopolysaccharide-induced memory impairment in mice.
Definition
ChEBI: A pentacyclic triterpenoid that is oleanane containing a double bond between positions 12 and 13 and substituted by hydroxy groups at the 3beta, 22beta and 24-positions.
Biological Activity
Soyasapogenol B is a constituent of soya bean saponin th at belongs to the family of oleanane triterpenes. It is known to have biofunctions in cell signaling, membrane integrity and stability, and fuel and energy storage. Soyasapogenol B may demonstrate hypocholesterolemic effects.
in vivo
Soyasapogenol B (25 or 50 mg/kg/day, intraperitoneal injection) can inhibit tumor growth, and promote apoptosis and autophagy in a mouse tumor model of colorectal cancer[1].
Soyasapogenol B (10 mg/kg, oral) alleviates memory impairment induced by lipopolysaccharide (HY-D1056) in mice by regulating the expression of BDNF mediated by NF-κB[3].
| Animal Model: | Xenograft murine models[1] |
| Dosage: | 25 or 50 mg/kg |
| Administration: | i.p. |
| Result: | Increased the apoptotic cell death dose-dependently. Increased the expression of cleaved caspase-3, Bax, CHOP, GRP78 and LC3BII. Decreased the expression of Bcl-2 and Ki-67. |
| Animal Model: | Lipopolysaccharide-induced memory impairment in mice[3] |
| Dosage: | 10 mg/kg |
| Administration: | p.o. |
| Result: | Increased LPS-suppressed BDNF expression and inhibited NF-κB activation and TNF-α expression. |
SOYASAPOGENOL B(P)Supplier
- Tel
- 13348960310
- 3003867561@qq.com
- Tel
- +86-21-20908456
- sales@BioChemBest.com
- Tel
- 0871-65217109 13211707573;
- y.liu@mail.biobiopha.com
- Tel
- +86-028-82633397 18982077548
- cwb1@biopurify.cn
- Tel
- 021-51320588
- tauto@tautobiotech.com
SOYASAPOGENOL B(P)(595-15-3)Related Product Information
- Silibinin
- Syringic acid
- 2-[(1Z,2E)-1-Hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dione
- Dihydromyricetin
- VERBENALIN
- syringaresinol
- Soyasaponin Ba
- Soyasaponin Aa
- SOYASAPOGENOL A(P)
- SOYASAPONIN I
- Daidzin
- PRIMAGEN PEPTONE FROM ANIMAL TISSUE
- beta-Sitosterol
- N/A
- SOYASAPOGENOL B(P)
- SOYASAPONIN IV
- (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8aR,9S,12aR,14aS,14bR)-9-hydro xy-4-(hydroxymethyl)-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8 ,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-5-[(2S,3R,4S,5S)-4,5 -dihydroxy-3-[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy -oxan-2-yl]oxy-3,4-dihydroxy-oxane-2-carboxylic acid
- SOYASAPONIN III