Eflone
Eflone Basic information
- Product Name:
- Eflone
- Synonyms:
-
- 9-fluoro-11β,17-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione 17-acetate
- FLUOROMETHOLONE ACETATE (200 MG)
- 9-fluoro-11b,17-dihydroxy-6a-methylpregna-1,4-diene-3,20-dione 17-acetate
- eflone
- fluorometholone acetate
- 9-fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 17-acetate
- Nolpitantium
- FLUROMETHOLONE ACETATE
- CAS:
- 3801-06-7
- MF:
- C24H31FO5
- MW:
- 418.5
- EINECS:
- 223-270-3
- Product Categories:
-
- Inhibitors
- Hormone Drugs
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Steroids
- Mol File:
- 3801-06-7.mol
Eflone Chemical Properties
- Melting point:
- 230-232°
- alpha
- D +28° (chloroform)
- Boiling point:
- 532.1±50.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 13.01±0.70(Predicted)
- color
- Off-White to Light Yellow
- InChIKey
- YRFXGQHBPBMFHW-ZGNMMXMRNA-N
- SMILES
- [C@]12(F)[C@@]([H])(O)C[C@]3(C)[C@](CC[C@@]3([H])[C@]1([H])C[C@]([H])(C)C1=CC(=O)C=C[C@]21C)(C(=O)C)OC(=O)C |&1:0,2,6,8,11,13,16,25,r|
Eflone Usage And Synthesis
Chemical Properties
Off-White to Pale Yellow Solid
Uses
Fluorometholone Acetate is a glucocorticoid; anti-inflammatory.
Definition
ChEBI: A steroid ester resulting from the formal condensation of the 17-hydroxy function of fluorometholone with acetic acid. Used in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.
brand name
Flarex (Alcon).
in vivo
Hourly topical administration of 0.1% Fluorometholone acetate ophthalmic suspension produced, on the average, a 47% reduction in the polymorphonuclear leukocytes invading the cornea during an experimentally induced inflammatory keratitis in New Zealand albino rabbits (1.5-2.0 kg). Fluorometholone acetate (0.1%) formulated as a high-viscosity carbomer gel and applied at three-hour intervals reduced invading leukocytes in the cornea an average of 48%, an effect not significantly different from hourly administration of the suspension[1].
IC 50
CA Ⅱ
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Eflone(3801-06-7)Related Product Information
- Benzyl acetate
- 2-Butoxyethyl acetate
- Fluorometholone
- Cellulose acetate
- Magnesium acetate
- Cupric acetate monohydrate
- Isopropyl acetate
- Butyl acetate
- Sodium acetate
- D-alpha-Tocopheryl acetate
- Vinyl acetate
- Ethylene glycol monoethyl ether acetate
- Ammonium acetate
- Ethyl acetate
- 1-Methoxy-2-propyl acetate
- ACETATE
- Eflone
- fluoro jade