ERYTHROMYCIN LACTOBIONATE (200 MG) Chemical Properties

Melting point:

145-150°

Density 

0.9083 (rough estimate)

refractive index 

1.5300 (estimate)

storage temp. 

Refrigerator

solubility 

Soluble in water, freely soluble in anhydrous ethanol and in methanol, very slightly soluble in acetone and in methylene chloride.

form 

Solid

color 

White to Off-White

Water Solubility 

>20g/L(21 ºC)

Safety Information

HS Code 

2941500000

ERYTHROMYCIN LACTOBIONATE (200 MG) Usage And Synthesis

Description

Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It is effective against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC₉₀s range from 0.015-2.0 mg/l). Erythromycin is known to potently inhibit the cytochrome P450 isoform CYP3A4, which can affect the metabolism of numerous clinically relevant medications. Erythromycin lactobionate is a soluble salt of erythromycin that is typically used for intraperitoneal or intravenous injections.

Chemical Properties

White or slightly yellow hygroscopic, powder.

Originator

Erythrocin,Abbott,US,1954

Uses

Erythromycin Lactobionate is an antibiotic used to reduce the prevalence of drug resistant bacteria as well as keeping constant the efficacy of other antibacterial drugs.

Uses

Macrolide antibacterial.

Manufacturing Process

A solution of erythromycin free base is prepared by dissolving 8.0 grams of erythromycin in 25 cc of acetone. 4.0 grams of lactobiono-delta-lactone is dissolved in 25 cc of water. The free lactobionic acid is formed in this solution and it has the molecular formula C12H22O12. The two solutions are mixed and evaporated to a gummy residue. This residue is dissolved in 60 cc of water and the solution is frozen and dried in vacuum by lyophilization. The dried residue of erythromycin lactobionate is a white amorphous powder and weighs 11.7 grams. The reaction product has an activity against B. subtilis of 420units per milligram. Its solubility in water is about 200 mg/cc and the melting point of the white powdery reaction product is 145° to 150°C.

brand name

Erythrocin (Abbott); Erythrocin (Hospira).

Therapeutic Function

Antibacterial

General Description

Erythromycin lactobionate is a water-soluble salt preparedby reacting erythromycin base with lactobiono-σ-lactone. Itoccurs as an amorphous powder that is freely soluble inwater and alcohol and slightly soluble in ether. It is intended,after reconstitution in sterile water, for intravenousadministration to achieve high plasma levels in the treatmentof serious infections.

ERYTHROMYCIN LACTOBIONATE (200 MG)(3847-29-8)Related Product Information

• Sodium lactobionate
• Sodium dichloroisocyanurate
• Cefuroxime
• PotassiuM sodiuM Dehydroandrographolide Succinate
• Lactobionic acid
• Azithromycin
• D-(+)-ALLOSE
• ERYTHROMYCIN A DIHYDRATE
• ERYTHROMYCIN LACTOBIONATE (200 MG)
• BETA-D-ALLOSE
• Gluconic acid
• N-DEMETHYL ERYTHROMYCIN A
• Erythromycin
• Ammonium-D-xylonate
• METHYL-BETA-D-RIBOPYRANOSE