2-CHLORO-N-METHYLACETOACETAMIDE Chemical Properties

Melting point:

78-80 °C

Boiling point:

284.1±30.0 °C(Predicted)

Density 

1.2253 (rough estimate)

refractive index 

1.5500 (estimate)

pka

10.01±0.46(Predicted)

EPA Substance Registry System

2-Chloro-N-methyl-3-oxobutanamide (4116-10-3)

Safety Information

Hazard Codes 

T

Risk Statements 

22-24-37/38-41-43

Safety Statements 

26-28-36/37/39-45

RIDADR 

2923

RTECS 

AK3910000

HazardClass 

8

PackingGroup 

III

Toxicity

mouse,LD50,oral,750mg/kg (750mg/kg),LUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: ANTIPSYCHOTIC,Archiv fuer Toxikologie. Vol. 18, Pg. 316, 1960.

2-CHLORO-N-METHYLACETOACETAMIDE Usage And Synthesis

Uses

2-Chloro-N-methyl-3-oxo-butanamide is used in the preparation of piperidinylmethyl (thiazolyl)phenylcarbamates which are useful as M3 muscarinic acetylcholine receptor antagonists for the treatment of chronic obstructive lung diseases, chronic bronchitis, asthma, and other disease.

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