2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE
2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE Basic information
- Product Name:
- 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE
- Synonyms:
-
- 2-(n-heptyl)-4-hydroxyquinolinen-oxide
- 2-heptyl-4-quinolino1-oxide
- hqno
- kf8940
- 2-Heptylquinolin-4-ol 1-oxide
- Antibiotic KF-8940
- Pyo II
- C04284
- CAS:
- 341-88-8
- MF:
- C16H21NO2
- MW:
- 259.34
- Mol File:
- 341-88-8.mol
2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE Chemical Properties
- Melting point:
- 156-157°
- Boiling point:
- 445.8±37.0 °C(Predicted)
- Density
- 1.09±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Soluble in DMSO (up to 8 mg/ml with warming), or in Ethanol (up to 13 mg/ml with warming).
- pka
- 1.07±0.40(Predicted)
- form
- White to off-white crystalline solid.
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE Usage And Synthesis
Description
HQNO (341-88-8) is a naturally occurring antagonist of dihydrostreptomycin. Potent inhibitor of the respiratory chain binding to the mitochondrial cytochrome b protein. HQNO inhibits NADH oxidase (NADH) and Na+-dependent NADH-quinone reductase (NQR).
Uses
HQNO is a streptomycin antagonist. A naturally occurring antagonist of dihydrostreptomycin.
Definition
ChEBI: 2-heptyl-4-hydroxyquinoline N-oxide is an inhibitor of the mitochondrial respiratory chain at cytochrome bc1 and of photosynthetic electron flow immediately before cytochrome b559. It is a monohydroxyquinoline and a quinoline N-oxide.
References
References/Citations 1) Nakayama?et al. (1999),?Inhibitor studies of a new antibiotic, korormicin, 2-n-heptyl-4-hydroxyquinoline N-oxide and Ag+?toward the Na+-translocating NADH-quinone reductase from the marine Vibrio alginolyticus; Biol. Pharm. Bull.,?221064
2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDESupplier
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2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE(341-88-8)Related Product Information
- A23187
- NONACTIN
- Nigericin sodium salt
- (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
- Pyridine-N-oxide
- Pyridine-4-carboxylic acid N-oxide
- QUINOLINE N-OXIDE HYDRATE
- 2-Pentylpyridine
- 2-Butylpyridine
- 4-HYDROXY-2-METHYLQUINOLINE
- 4-Hydroxy-2-methylpyridine
- 2-Hexylpyridine
- Quinoline-N-oxide
- 4-HYDROXYPYRIDINE-1-OXIDE
- 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE
- 2-Ethylquinoline
- 2-ETHYL-PYRIDINE 1-OXIDE
- 2-PICOLINE-N-OXIDE