SILYBIN (MIXTURE OF SILYBIN A AND SILYBIN B) Chemical Properties

Melting point:

160 °C

Boiling point:

793.0±60.0 °C(Predicted)

Density 

1.527±0.06 g/cm3(Predicted)

storage temp. 

Freezer

pka

7.39±0.60(Predicted)

form 

powder to crystaline

color 

White to Orange to Green

Merck 

14,8532

Safety Information

RTECS 

DJ2981770

HS Code 

2932.99.7000

SILYBIN (MIXTURE OF SILYBIN A AND SILYBIN B) Usage And Synthesis

Uses

(±)-Silybin is the racemate of Silybin (HY-N0779A). Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].

Definition

ChEBI: Silibinin is a flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities. It has a role as an antioxidant, an antineoplastic agent, a hepatoprotective agent and a plant metabolite. It is a flavonolignan, a polyphenol, an aromatic ether, a benzodioxine and a secondary alpha-hydroxy ketone.

References

[1] Silvia Zappavigna, et al. Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma Cells. Int J Mol Sci. 2019 May 3;20(9):2190. DOI:10.3390/ijms20092190
[2] Runbin Sun, et al. Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model. Biomed Pharmacother. 2020 Mar;123:109721. DOI:10.1016/j.biopha.2019.109721