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HOLOCALIN(P)

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HOLOCALIN(P) Basic information

Product Name:
HOLOCALIN(P)
Synonyms:
  • Halocaine
  • Holocaine
  • n,n’-bis(4-ethoxyphenyl)-ethanimidamid
  • n,n’-bis(4-ethoxyphenyl)ethanimidamidemonohydrochloride
  • n,n’-bis(p-ethoxyphenyl)-acetamidin
  • n,n’-bis(p-ethoxyphenyl)acetamidine
  • N',N2-Bis(p-ethoxyphenyl)acetamidine
  • N,N'-Bis(p-ethoxyphenyl)acetamidine
CAS:
101-93-9
MF:
C18H22N2O2
MW:
298.38
Product Categories:
  • Alkaloids
Mol File:
101-93-9.mol
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HOLOCALIN(P) Chemical Properties

Melting point:
117°C
Boiling point:
439.8°C (rough estimate)
Density 
1.1301 (rough estimate)
refractive index 
1.5350 (estimate)
pka
9.95±0.50(Predicted)
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HOLOCALIN(P) Usage And Synthesis

Originator

Phenacaine, ZYF Pharm Chemical

Definition

ChEBI: Phenacaine is an aromatic ether.

Manufacturing Process

Phenacetin (4-ethoxyacetanilide) was treated with slowly current of gaseous hydrogen chloride for 15 hours at 150°C. On cooling the product was poured into 20 volumes of water and heated. Then it was cooled to room temperature, filtered off and excess of alkali was added. The precipitated crude product was at first re-crystallized from 60% ethanol, then from benzene-ligroin to give pure acetamidine as a white needles; MP: 121°C.

brand name

Holocaine Hydrochloride (Abbott).

Therapeutic Function

Local anesthetic

HOLOCALIN(P)Supplier

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