2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS Chemical Properties

Melting point:

178-180°C

Boiling point:

464.5±45.0 °C(Predicted)

Density 

1.447±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

1.52±0.50(Predicted)

color 

Yellow

InChIKey

ZVCIIRBNNSUNCH-UHFFFAOYSA-N

Safety Information

WGK Germany 

3

2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

Intermediate in the preparation of Flupirtine metabolites.

Synthesis

To a reaction flask was added 200 mL of methanol, 52.08 g of 2-amino-3-nitro-6-chloropyridine (compound 1), 37.54 g of p-fluorobenzylamine and 50.0 mL of triethylamine. The reaction mixture was heated to 80 °C and kept for 10 hours. After completion of the reaction, 10 times the volume of water was added to the reaction solution and a solid was precipitated, which was filtered and dried to give 76.47 g of 2-amino-3-nitro-6-(4-fluorobenzylamino)pyridine (Compound 3) in 97.2% yield and 99.62% purity (as determined by HPLC).

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 23, p. 9739 - 9756
[2] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2012, vol. 67, # 12, p. 1297 - 1304
[3] Patent: CN105541705, 2016, A. Location in patent: Paragraph 0013; 0027; 0028
[4] Patent: WO2012/4391, 2012, A1. Location in patent: Page/Page column 39
[5] Patent: CN104086481, 2016, B. Location in patent: Paragraph 0033 - 0037

2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS(33400-49-6)Related Product Information

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• 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS