cis-Diamminediiodoplatinum Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

Appearance

Yellow to orange Solid

InChI

InChI=1S/2HI.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2

InChIKey

PNCHTLQBARZRSO-UHFFFAOYSA-L

SMILES

[Pt+2]([NH3])([NH3])([I-])[I-]

EPA Substance Registry System

Platinum, diamminediiodo-, (SP-4-2)- (15978-93-5)

cis-Diamminediiodoplatinum Usage And Synthesis

Uses

cis-Diiododiammineplatinum(II) is a diiodo analog of cis-platin. cis-Diiododiammineplatinum(II) exhibits similar DNA binding modes as cis-platin by greater DNA reactivities towards tumor cell lines.

Pharmaceutical Applications

cis-Diamminediiodoplatinum was first reported in 1844 and named Peyrone's chloride after its inventor. Recently, this compound has been of particular interest because it has been found to have anti-cancer activity.

Synthesis

A process for preparing a cis-diamminediiodoplatinum(II) complex of high purity and in high yield from potassium tetraiodoplatinum(II) by a method comprising adding an aqueous solution of ammonium hydroxide to an aqueous dispersion of potassium tetraiodoplatinum(II), said tetraiodo compound having the formula K2 PtI4, under a controlled gradually rising temperature profile while controlling the ammonium hydroxide addition so that the pH does not exceed about 7.5.

cis-Diamminediiodoplatinum(15978-93-5)Related Product Information

• Cisplatin
• Carboplatin
• Nedaplatin
• LOBAPLATIN
• DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
• Picoplatin
• Eptaplatin
• Satraplatin
• (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate
• DIBROMO(1,5-CYCLOOCTADIENE)PLATINUM(II)
• PLATINUM(IV) IODIDE
• cis-Diamminediiodoplatinum