N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide Chemical Properties

Melting point:

>251°C (dec.)

Boiling point:

554.8±60.0 °C(Predicted)

Density 

1.742±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

DMSO, Methanol

form 

Solid

pka

10.90±0.70(Predicted)

color 

Off-White to Pale Beige

CAS DataBase Reference

171887-03-9(CAS DataBase Reference)

Safety Information

HS Code 

2933.59.9500

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide Usage And Synthesis

Chemical Properties

White crystalline powder

Uses

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide (Abacavir - In House Impurity) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Uses

Prasugrel intermediate

Uses

Abacavir intermediate. A purine derivative

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide(171887-03-9)Related Product Information

• ALTRENOGEST
• 4,6-Dichloropyrimidine
• 2-Amino-4,6-dichloropyrimidine
• p-Aminobenzamide
• Tris(hydroxymethyl)aminomethane
• Benzamide
• Dichloroacetic acid
• 6-Aminocaproic acid
• Formamide
• Glycine
• Chlorantraniliprole
• 2-Aminopyrimidine
• N,N-Dimethylformamide
• 5-Cyanophthalide
• 2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride
• 1,2,3-Triacetyl-5-deoxy-D-ribose
• 5-Amino-4,6-dichloropyrimidine
• 2,5-Diamino-4,6-dichloropyrimidine