m-PEG9-COOH Chemical Properties

Boiling point:

536.3±50.0 °C(Predicted)

Density 

1.111±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, sealed storage, away from moisture

pka

4.28±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

InChI

InChI=1S/C20H40O11/c1-23-4-5-25-8-9-27-12-13-29-16-17-31-19-18-30-15-14-28-11-10-26-7-6-24-3-2-20(21)22/h2-19H2,1H3,(H,21,22)

InChIKey

HVDSDOIAPZITDA-UHFFFAOYSA-N

SMILES

C(O)(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOC

m-PEG9-COOH Usage And Synthesis

Uses

m-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Biological Activity

m-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

m-PEG9-COOH(2576495-35-5)Related Product Information

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