m-PEG9-COOH Chemical Properties

Boiling point:

536.3±50.0 °C(Predicted)

Density 

1.111±0.06 g/cm3(Predicted)

pka

4.28±0.10(Predicted)

m-PEG9-COOH Usage And Synthesis

Biological Activity

m-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

m-PEG9-COOH(2576495-35-5)Related Product Information

• m-PEG10-acid
• m-PEG9-CHO
• NONAETHYLENE GLYCOL MONOMETHYL ETHER
• m-PEG9-Tos
• MPEG8-NHS
• 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-amine
• m-PEG9-bromide
• 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosane-28-thiol
• m-PEG9-Mal
• 3,6,9,12,15,18,21,24,27-Nonaoxaoctacosanoic acid