WNT3A Antibody Usage And Synthesis

Source

Rabbit

Applications

WNT3A antibody has been tested by ELISA, Western blot and immunohistochemistry analysis to assure specificity and reactivity.  

Reactivity

Mouse

Immunogen

Anti-human WNT3A mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human WNT3A amino acids 19-352 purified from E. coli.

Background

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins are implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT3A is a member of the WNT gene family. WNT3A is a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. The WNT3A gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.

References

[1] Cadigan, K.M. and Nusse, R. (1997) Genes Dev. 11, 3286-3305.
[2] Moon, R.T. et al. (1997) Trends Genet. 13, 157-162.
[3] Kohn, A.D. and Moon, R.T. (2004) Cell Calcium 38, 439-446.
[4] Logan, C.Y. and Nusse, R. (2004) Annu. Rev. Cell Dev. Biol. 20, 781-810.
[5] Giles, R.H. et al. (2003) Biochim. Biophys. Acta. 1653, 1-24.
[6] Willert, K. et al. (2003) Nature 423, 448-52.
[7] Katoh, M. (2001) Int. J. Oncol. 19, 977-82.

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