CDCA5 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human

Background

Cohesin is a ring-shaped multiprotein complex that functions in sister chromatid cohesion and in establishing higher order chromosome structure. The cohesin complex regulates chromosome segregation, DNA repair, and transcription.CDCA5 stabilizes the cohesin complex on DNA through inhibition of the cohesion antagonist WAPL. CDCA5 promotes cell proliferation and inhibits apoptosis through the AKT signaling pathway in hepatocellular carcinoma cells. Overexpression of CDCA5 indicates poor prognosis in HCC.

References

[1] Barbero, J.L. (2009) Cell Mol Life Sci 66, 2025-35.
[2] Waldman, T. (2020) Nat Rev Cancer 20, 504-515.
[3] Nishiyama, T. et al. (2010) Cell 143, 737-49.
[4] Chen, H. et al. (2019) J Cancer 10, 1846-1854.
[5] Tian, Y. et al. (2018) BMC Cancer 18, 1187.
[6] Wang, J. et al. (2018) Oncol Rep 40, 1875-1884.
[7] Shen, Z. et al. (2018) Onco Targets Ther 11, 891-901.

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