E2F1 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human

Background

The E2F transcription factors are essential for regulation of the cell cycle. Physiological E2F is a heterodimer composed of an E2F subunit together with a DP subunit. Six members of the E2F family have been identified, and each E2F subunit has a DNA binding and a dimerization domain. E2F-1 to -5 activate transcription. E2F-1 to -3 bind pRb, and E2F-4 and -5 bind p107 or p130, and these interactions are under cell cycle control. E2F-1 has oncogenic properties in vivo and in vitro. E2F-1 can induce apoptosis through p53-dependent and -independent mechanisms. E2F-1 is stress-responsive, and is regulated by a PI3-kinase-like kinase family such as the ATM/ATR kinases.

References

[1] Helin, K. (1998) Curr. Opin. Genet. Dev. 8, 28-35.
[2] Dyson, N. (1998) Genes Dev. 12, 2245-2262.
[3] Helin, K. et al. (1993) Genes Dev. 7, 1850-1861.
[4] Wu, C. et al. (1995) Mol. Cell. Biol. 15, 2536-2546.
[5] Takahashi, Y. et al. (2000) Genes Dev. 14, 804-816.
[6] Wu, L. et al. (2001) Nature 414, 457-462.
[7] Gaubatz, S. et al. (2000) Mol. Cell 6, 729-735.
[8] Hurford, R. K. et al. (1997) Genes Dev. 11, 1447-1463.
[9] Tsai, K. Y. et al. (1998) Mol. Cell 2, 293-304.
[10] Garcia, I. et al. (2000) Cell Growth Differ. 11, 91-98.

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