IRAK 2 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

Interleukin-1 receptor-associated kinase is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor. The mammalian family of IRAK molecules contains four members. The binding of IL-1 to IL-1 receptor type I initiates the formation of a complex that includes IL-1RI, AcP, MyD88, and IRAKs. IRAK undergoes autophosphorylation shortly after IL-1 stimulation. The subsequent events involve IRAK dissociation from the IL-1RI complex, its ubiquitination, and its association with two membrane-bound proteins: TAB2 and TRAF6. The resulting IRAK-TRAF6-TAB2 complex is then released into the cytoplasm where it activates protein kinase cascades, including TAK1, IKKs, and the stress-activated kinases.Unlike IRAK1 and IRAK4, IRAK2 and IRAK-M do not have significant kinase activity although they can still activate NF-κB when overexpressed. Antisense oligonucleotide depletion of IRAK2 can inhibit IL-1 mediated NF-κB activation.

References

[1] Dinarello, C.A. (1996) Blood 87, 2095-147.
[2] Takaesu, G. et al. (2001) Mol Cell Biol 21, 2475-84.
[3] Janssens, S. and Beyaert, R. (2003) Mol Cell 11, 293-302.
[4] Wesche, H. et al. (1999) J Biol Chem 274, 19403-10.
[5] Muzio, M. et al. (1997) Science 278, 1612-5.
[6] Guo, F. et al. (1999) Inflammation 23, 535-43.

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