MEF2A antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human

Background

MEF2A is a member of the MEF2 family of transcription factors. In mammals, four MEF2A-related genes encode proteins which exhibit significant amino acid sequence similarity within their DNA binding domains and to a lesser extent throughout the remaining proteins. The MEF2 family members were originally described as muscle-specific DNA binding proteins that recognize MEF2 motifs found within the promoters of many muscle-specific genes. Phosphorylation of MEF2A at Thr312 and Thr319 within the transcription activation domain by p38 MAP kinase enhances MEF2A-MEF2D heterodimer-dependent gene expression. On the other hand, apoptotic stimuli result in CDK5-dependent phosphorylation of MEF2A at Ser408 within the activation domain, inhibiting MEF2A pro-survival function.

References

[1] Shore, P. et al. (1995) Eur. J. Biochem. 229, 1-13.
[2] Martin, J.F. et al. (1994) Mol. Cell. Biol. 14, 1647-1656.
[3] Yu, Y.T. et al. (1992) Genes Dev. 6, 1783-1798.
[4] Zhao, M. et al. (1999) Mol. Cell. Biol. 19, 21-30.
[5] Gong, X. et al. (2003) Neuron 38, 33-46.

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