PTBP2 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

PTBP1 and PTBP2 are highly related pre-mRNA binding proteins that silence the splicing of alternative exons. While PTBP1 is widely expressed, PTBP2, also known as neural PTB or nPTB, is expressed in post-mitotic neurons. In other cell types, PTBP2 transcripts are alternatively spliced by PTBP1, which leads to nonsense-mediated decay. PTBP1 and 2 bind to similar regions across the transcriptome, but PTBP1 has a stronger repressive property likely due to cofactors such as Raver1 and Matrin3. Overexpression of PTBPs in various cancers has been observed, leading to alternative splicing of key proteins in oncogenic pathways.

References

[1] Amir-Ahmady, B. et al. (2005) RNA 11, 699-716.
[2] Oberstrass, F.C. et al. (2005) Science 309, 2054-7.
[3] Boutz, P.L. et al. (2007) Genes Dev 21, 1636-52.
[4] Keppetipola, N.M. et al. (2016) RNA 22, 1172-80.
[5] Vuong, J.K. et al. (2016) Cell Rep 17, 2766-2775.
[6] Minami, K. et al. (2017) Oncotarget 8, 33064-33077.
[7] Wang, Z.N. et al. (2017) Oncotarget 8, 36185-36202.
[8] Uemura, Y. et al. (2017) Genes Cells 22, 785-798.
[9] Bielli, P. et al. (2018) Clin Cancer Res 24, 5422-5432.

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