RBM10 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Rat;Monkey

Background

RBM10 is an RNA binding protein and a paralog to tumor suppressor RBM5. Alternative splicing creates two highly expressed variants that differ by one exon. RBM10 controls alternative splicing and exon skipping of mRNAs, including Fas and Bcl-x. RBM10 has been shown to affect apoptosis via up regulation of TNF-α mRNA. In lung cancer, RBM10 mutations disrupt the splicing of NUMB, a regulator of Notch signaling. Fusion of the RBM10 gene with TFE3 has been found in renal cell carcinoma. Mutations of RBM10 causes TARP syndrome, an x-linked, lethal disorder characterized by various developmental defects.

References

[1] Timmer, T. et al. (1999) Genomics 60, 238-40.
[2] Bonnal, S. et al. (2008) Mol Cell 32, 81-95.
[3] Wang, Y. et al. (2013) EMBO Mol Med 5, 1431-42.
[4] Inoue, A. et al. (2014) FEBS Lett 588, 942-7.
[5] Wang, K. et al. (2012) J Cell Death 5, 1-19.
[6] Bechara, E.G. et al. (2013) Mol Cell 52, 720-733.
[7] Hernández, J. et al. (2016) RNA Biol 13, 466-472.
[8] Just, P.A. et al. (2016) Genes Chromosomes Cancer 55, 541-548.
[9] Argani, P. et al. (2017) Am J Surg Pathol 41, 655-662.
[10] Gorlin, R.J. et al. (1970) Am J Dis Child 119, 176-8.

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