SF3A3 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

The mammalian splicing factor SF3a contains three primary subunits: SF3A1, SF3A2, and SF3A3 which, along with SF3b, activate the U2 snRNP to form the pre-mRNA splicing complex. SF3A2 and SF3A3 both interact with SF3A1, but not with each other, and SF3A3 plays a major role in recruiting SF3A1 to the complex. Each protein in the heterotrimer has been shown to be essential for mRNA splicing and cell viability. Notably, SF3a plays a role in growth factor signaling as SF3A1 can bind to ERalpha when phosphorylated at Ser118 to affect downstream splicing. SF3a also plays a role in the innate immune response, as it promotes inflammation by splicing the TLR adaptor Myd88. Furthermore, SF3a regulates a number of genes involved in innate immune signaling pathways in macrophages versus other pathways.

References

[1] Brosi, R. et al. (1993) Science 262, 102-5.
[2] Brosi, R. et al. (1993) J Biol Chem 268, 17640-6.
[3] Nesic, D. and Krämer, A. (2001) Mol Cell Biol 21, 6406-17.
[4] Tanackovic, G. and Krämer, A. (2005) Mol Biol Cell 16, 1366-17.
[5] Masuhiro, Y. et al. (2005) Proc Natl Acad Sci U S A 102, 8126-31.
[6] De Arras, L. and Alper, S. (2013) PLoS Genet 9, e1003855.
[7] O'Connor, B.P. et al. (2015) PLoS Genet 11, e1004932.

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