Benralizumab
Benralizumab Basic information
- Product Name:
- Benralizumab
- Synonyms:
-
- Benralizumab
- BIW-8405
- MEDI-563
- Research Grade Benralizumab(DHF86301)
- BIW-8405|||MEDI-563
- Research Grade Benralizumab
- Benralizumab (anti-IL-5Ra)
- CAS:
- 1044511-01-4
- MW:
- 0
- Mol File:
- Mol File
Benralizumab Chemical Properties
- storage temp.
- Store at 4°C, do not freeze
- solubility
- Soluble in DMSO
- form
- Liquid
- color
- Colorless to light yellow
Benralizumab Usage And Synthesis
Uses
Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma[1].
in vivo
Benralizumab (MEDI-563) (0-30 mg/kg; i.v.; once every 3 weeks for 12 weeks) reduces peripheral blood and bone marrow eosinophil[2].
| Animal Model: | Female and male cynomolgus monkeys[2] |
| Dosage: | 0.1, 1, 10, and 30 mg/kg |
| Administration: | Intravenous injection, once every 3 weeks for 12 weeks |
| Result: | Blood eosinophil counts decreased close to the limit of detection after the first administration at all dose levels and remained undetectable. Eosinophil precursors in the bone marrow were reduced 80% or greater in all doses 3 days after the last administration (terminal necropsy) and remained undetectable until 18 days after the last dose in the 30 mg/kg group. The profound effect observed in the bone marrow was specific for the eosinophil lineage. |
IC 50
IL-5Rα
References
[1] Menzies-Gow A, et al. Corticosteroid tapering with benralizumab treatment for eosinophilic asthma: PONENTE Trial. ERJ Open Res. 2019 Sep 25;5(3). pii: 00009-2019. DOI:10.1183/23120541.00009-2019
[2] Kolbeck R, et al. MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. J Allergy Clin Immunol. 2010 Jun;125(6):1344-1353.e2. DOI:10.1016/j.jaci.2010.04.004
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