Sennoside A
Sennoside A Basic information
- Product Name:
- Sennoside A
- Synonyms:
-
- Sennoside A std.
- SENNOSIDEA60%
- SENNOSIDE A(P)
- SENNOSIDE A(SH)
- SENNOSIDA
- CALCIUM SENNOSIDE 5%, 10%, 20%, 60%
- [9,9'-Bianthracene]-2,2'-dicarboxylicacid,5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-,(9R,9'R)-
- Sennoside A1
- CAS:
- 81-27-6
- MF:
- C42H38O20
- MW:
- 862.74
- EINECS:
- 201-339-9
- Product Categories:
-
- The group of Sennosides
- Anthraquinones, Hydroquinones and Quinones
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Inhibitors
- Mol File:
- 81-27-6.mol
Sennoside A Chemical Properties
- Melting point:
- >191oC (dec.)
- alpha
- D20 -164° (c = 0.1 in 60% acetone); D20 -147° (c = 0.1 in 70% acetone); D20 -24° (c = 0.2 in 70% dioxane)
- Boiling point:
- 1144.8±65.0 °C(Predicted)
- Density
- 1.743±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated)
- form
- Solid
- pka
- 3.31±0.40(Predicted)
- color
- Yellow to Dark Yellow
- BRN
- 5723746
- Stability:
- Hygroscopic
- InChIKey
- IPQVTOJGNYVQEO-KGFNBKMBSA-N
- LogP
- 1.880 (est)
MSDS
- Language:English Provider:SigmaAldrich
Sennoside A Usage And Synthesis
Chemical Properties
Light yellow powder
Uses
a natural anthroquinonone glucoside calcium complex with laxative properties
Uses
Sennoside A is used as a laxative in the treatment of constipation. In addition. it is hypothesized to induce cell proliferation and may be a potential carcinogenic agent.
Definition
ChEBI: Sennoside A is a member of the class of sennosides that is rel-(9R,9'R)-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid which is substituted by hydroxy groups at positions 4 and 4', by beta-D-glucopyranosyloxy groups at positions 5 and 5', and by oxo groups at positions 10 and 10'. The exact stereochemisty at positions 9 and 9' is not known - it may be R,R (as shown) or S,S. It is a member of sennosides and an oxo dicarboxylic acid.
in vivo
Sennoside A (25 mg/kg, 50 mg/kg; intragastric gavage for 12 weeks) alters the gut microbiome composition of type 2 diabetes (T2D) mice and mediates anti-obesity effects[3].
Sennoside A also reduces inflammation and increases tight junction proteins in the ileum of genetically defective mice[3].
IC 50
HIV-1
Purification Methods
Sennoside A (bianthraquinonyl-bis-glucoside R,R-enantiomer) [81-27-6] M 862.7, m 220 -2 4 0o(dec), [ ] D -164o (c 0.1, Me2CO/H2O 6:4), [ ] D -24o (c 0.2, 70% aqueous dioxane). Sennoside A forms yellow crystals from aqueous acetone, 2-ethoxyethanol or large volumes of H2O. [Stoll et al. Helv Chim Acta 32 1896 1900, Beilstein 17 III/IV 3403.]
Sennoside ASupplier
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
- Tel
- +86-21-20908456
- sales@BioChemBest.com
- Tel
- 025-83697070
- info@chemlin.com.cn
- Tel
- 400-1166-196 18981987031
- cdhxsj@163.com
- Tel
- 0086-21-58956006
Sennoside A(81-27-6)Related Product Information
- Sennoside C,Sennoside C
- Sennoside D,Sennoside D
- Sennoside B
- SENNIDINE A
- 2,2'-DIHYDROXYBENZOPHENONE
- 4-FORMYL-3-HYDROXYBENZOIC ACID
- 4-Acetylbenzoic acid
- 5-ISOPROPYL-3-METHYLPHENOL
- 4-BROMOBENZHYDROL
- BIANTHRONYL
- 4-ETHYL-3-HYDROXYBENZOIC ACID
- 1,1,2,2-TETRAPHENYLETHANE
- SENNOSIDE,SENNOSIDE A AND B,SENNOSIDE A AND B,SENNOSIDE
- 3-Hydroxy-4-methylbenzoic acid
- HELICIN
- SENNOSIDES
- 3-HYDROXY-5-METHYL-BENZOIC ACID
- 3-ISOBUTYL-BENZOIC ACID