3-Methylaminopropionitrile Chemical Properties

Melting point:

49-50 °C

Boiling point:

182-186 °C

Density 

0.899 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.432(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform, Methanol

pka

8.27±0.10(Predicted)

form 

Liquid

color 

Clear yellow

BRN 

1699160

InChIKey

UNIJBMUBHBAUET-UHFFFAOYSA-N

CAS DataBase Reference

693-05-0(CAS DataBase Reference)

NIST Chemistry Reference

Propanenitrile, 3-(methylamino)-(693-05-0)

EPA Substance Registry System

Propanenitrile, 3-(methylamino)- (693-05-0)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21-36/37/38

Safety Statements 

26-36/37-37/39

WGK Germany 

3

RTECS 

TZ4910000

HazardClass 

IRRITANT

HS Code 

29269095

MSDS

• Language:English Provider:3-Methylaminopropionitrile
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

3-Methylaminopropionitrile Usage And Synthesis

Chemical Properties

CLEAR YELLOW LIQUID

Uses

(3-MethylaMinopropionitrile) Aminoproponitriles can be used as inhibitors of oxidase enzymes and as a reagent for aminomethylphosphine ligands or the synthesis of aminobenzothiazoles.

Synthesis

Below 15 °C, 160.8 g (3.0 mol, 99% purity) of 2-acrylonitrile was slowly added dropwise to 345.1 g (3.0 mol, 27% concentration) of monomethylamine solution while maintaining stirring. Upon completion of the reaction, the ethanol generated was removed by distillation at atmospheric pressure. The product was subsequently collected by vacuum distillation to give 210.6 g of 3-methylaminopropionitrile in 83.5% yield.

References

[1] Kinetics and Catalysis, 2010, vol. 51, # 5, p. 653 - 656
[2] Journal of Heterocyclic Chemistry, 1997, vol. 34, # 1, p. 87 - 91
[3] Patent: CN106632280, 2017, A. Location in patent: Paragraph 0023; 0024; 0025
[4] Patent: CN108003141, 2018, A. Location in patent: Paragraph 0032; 0035
[5] Liebigs Annalen der Chemie, 1980, # 9, p. 1438 - 1447

3-Methylaminopropionitrile(693-05-0)Related Product Information

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