R(+)-Baclofen.Hydrochloride
R(+)-Baclofen.Hydrochloride Basic information
- Product Name:
- R(+)-Baclofen.Hydrochloride
- Synonyms:
-
- (+)-r-3-(p-chlorophenyl)-4-aminobutanoicacidhydrochloride
- (r)-baclofenmonohydrochloride
- beta-(aminomethyl)-4-chloro-,hydrochloride,(r)-benzenepropanoicaci
- beta-(aminomethyl)-p-chloro-,hydrochloride,(r)-hydrocinnamicaci
- d-baclofenhydrochloride
- R(+)-BACLOFEN HYDROCHLORIDE
- R(+)-BETA-(AMINOMETHYL)-4-CHLOROBENZENEPROPANOIC ACID HCL
- R(+)-BETA-(AMINOMETHYL)-4-CHLOROBENZENEPROPANOIC ACID HYDROCHLORIDE
- CAS:
- 63701-55-3
- MF:
- C10H13Cl2NO2
- MW:
- 250.12
- Product Categories:
-
- GABA/Glycine receptor
- Mol File:
- 63701-55-3.mol
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R(+)-Baclofen.Hydrochloride Chemical Properties
- Melting point:
- 220～222℃
- storage temp.
- Store at -20°C
- solubility
- DMSO: >20 mg/mL
- form
- solid
- color
- white
- optical activity
- [α]28/D +3.8°, c = 0.9 in methanol(lit.)
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Safety Information
- Safety Statements
- 24/25
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- MW5084350
MSDS
- Language:English Provider:SigmaAldrich
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R(+)-Baclofen.Hydrochloride Usage And Synthesis
Uses
R(+)-Baclofen.Hydrochloride is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.
Biochem/physiol Actions
R(+)-Baclofen is a GABAB receptor agonist; more active enantiomer; skeletal muscle relaxant.
in vivo
(R)-Baclofen hydrochloride (STX 209 hydrochloride) suppresses audiogenic seizures in the Fmr1-knockout mouse on the seizure-resistant C57BL/6 background with an effective dose of 1 mg/kg[3].
Acute intraperitoneal administration of (R)-Baclofen hydrochloride significantly reduces the percent of mice displaying seizures (seizure incidence), with a minimum effective dose (MED) of 1.5 mg/kg[3].
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