GRAMICIDIN A
GRAMICIDIN A Basic information
- Product Name:
- GRAMICIDIN A
- Synonyms:
-
- OHC-NH-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-CONCH2CH2OH
- OHC-NH-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-CONHCH2CH2OH
- GA
- HCO-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-NHCH2CH2OH
- HCO-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-NHCH2CH2OH
- HCO-X-GLY-L-ALA-D-LEU-L-ALA-D-VAL-L-VAL-D-VAL-L-TRP-D-LEU-L-TRP-D-LEU-L-TRP-D-LEU-L-TRP-NHCH2CH2OH
- GRAMICIDIN A
- GRAMICIDIN A, BACILLUS BREVIS
- CAS:
- 11029-61-1
- MF:
- C99H140N20O17
- MW:
- 1882.29
- EINECS:
- 234-259-8
- Product Categories:
-
- Interferes with Cell Membrane Permeability (Ionophores)Antibiotics
- A - KAntibiotics
- Antibacterial
- Antibiotics A to
- Antibiotics G-MAntibiotics
- Chemical Structure Class
- Inhibits an EnzymeAntibiotics
- Mechanism of Action
- Peptides
- Spectrum of Activity
- Mol File:
- 11029-61-1.mol
GRAMICIDIN A Chemical Properties
- storage temp.
- 2-8°C
- solubility
- ethanol: soluble
- form
- White to off-white solid
- color
- colorless or white
- BRN
- 6461131
GRAMICIDIN A Usage And Synthesis
Uses
Gramicidin A is an effective antibiotic against Gram positive organisms.
Purification Methods
Purify gramicidin A by countercurrent distribution from *C6H6/CHCl3, MeOH/H2O (15:15:23:7) with 5000 tubes. Fractions are examined by UV (280nm) of small aliquots. Separation from gramicidin C and other material occurred after 999 transfers. [Gross & Witkop Biochemistry 4 2495 1965, Bauer et al. Biochemistry 11 3266 1972.] Purify it finally by recrystallisation from EtOH/H2O and dry it at 100o/10-2mm over KOH. It forms platelets m 229-230o. It is almost insoluble in H2O (0.6%) but soluble in lower alcohols, dry Me2CO, dioxane, acetic acid and pyridine. The commercial material is more difficult to crystallise than the synthetic compound. [Sarges & Witkop J Am Chem Soc 86 1861 1964, 87 2011, 2020 1965.] It has characteristic [] D20 +27.3o (c 1.3, MeOH) and UV max at 282nm ( 22,100). The N-carbamoyldeformyl gramicidine A precipitates from EtOAc/pet ether (b 40-60o). [Beilstein 26 III/IV 4273.]
GRAMICIDIN ASupplier
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- 010-82848833 400-666-7788
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- info@creative-peptides.com
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GRAMICIDIN A(11029-61-1)Related Product Information
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- Gramicidin >95%,Gramicidin/CH63857,gramicidin from bacillus brevis,GRAMICIDIN D [DUBOS],GRAMICIDIN D,GRAMICIDIN
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- GRAMICIDIN A
- GRAMICIDIN S,Gramicidin S1,Gramicidin S-A,Soviet Gramicidin C,GRAMICIDIN C
- GRAMICIDIN C FROM BACILLUS BREVIS
- GRAMICIDIN
- diagnosis latex microsphors combining anti fetoprotein
- AFP Casset
- AFP Strip
- AFP (anti-Alpha Fetoprotein(AFP), for conjugation and detection)
- Gramicidin S hydrochloride
- Α-FETOPROTEIN
- gramicidin A, 7-alanine-
- [Val1]gramicidin A,Gramicidin A 1-L-Val
- Gramicidin S3
- gramicidin-S-synthetase 2
- gramicidin(micro) usp23,