Etoposide phosphate
Etoposide phosphate Basic information
- Product Name:
- Etoposide phosphate
- Synonyms:
-
- ETOPOPHOS
- ETOPOSIDE PHOSPHATE
- ETOPOSIDE PHOSPHONATE
- ETOPOSIDE PHOSPHONATE, ETOPOPHOS
- BMY-40481, Etoposide 4'-Dihydrogenphosphate
- Etoposide 4'-Phosphate
- (5R,5aR,8aR,9S)-5-[3,5-DiMethoxy-4-(phosphonooxy)phenyl]-9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
- [5R-[5α,5aβ,8aα,9β(R*)]]-5-[3,5-DiMethoxy-4-(phosphonooxy)phenyl]-9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
- CAS:
- 117091-64-2
- MF:
- C29H33O16P
- MW:
- 668.54
- EINECS:
- 630-364-1
- Product Categories:
-
- Antineoplastic
- Carbohydrates & Derivatives
- Drug Analogues
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- API
- Mol File:
- 117091-64-2.mol
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Etoposide phosphate Chemical Properties
- Boiling point:
- 907.7±75.0 °C(Predicted)
- Density
- 1?+-.0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- form
- Solid
- pka
- 1.13±0.50(Predicted)
- color
- White to off-white
- Water Solubility
- Water: 125 mg/mL (186.97 mM)
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Etoposide phosphate Usage And Synthesis
Chemical Properties
White crystalline powder
Uses
As a bioequivalent prodrug of the DNA topoisomerase II inhibitor Etoposide (E933750), Etoposide phosphate can be used in the treatment of a wide variety of hematological malignancies and solid tumors.
Definition
ChEBI: Etoposide phosphate is a furonaphthodioxole.
brand name
Etopophos (Bristol-Myers Squibb).
in vivo
Etoposide phosphate (intravenous injection; 50, 100, or 150 mg/kg; single dose) has clinical symptomology of progressive ataxia, impaired righting reflex, and splaying and paresis of fore- and hindlimbs at day 8?in female CD-1 mice[3].
| Animal Model: | Female CD-1 mice[3] |
| Dosage: | 50, 100, or 150 mg/kg |
| Administration: | Intravenous injection; single dose |
| Result: | Observed degeneration of dorsal root ganglion cells and axonal degeneration of their distal and proximal processes in peripheral nerves, dorsal spinal roots, and dorsal funiculi of the spinal cord at all doses under light microscopy (LM). |
IC 50
Topoisomerase II
Etoposide phosphateSupplier
J & K SCIENTIFIC LTD.
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- 010-82848833 400-666-7788
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- +86-21-20908456
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Chemsky（shanghai）International Co.,Ltd.
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Shanghai Ennopharm Co., Ltd.
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- +86 (21) 6435-5022
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Etoposide phosphate(117091-64-2)Related Product Information
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