2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID Chemical Properties

Melting point:

178-185°C dec.

Boiling point:

432.7±45.0 °C(Predicted)

Density 

1.520±0.06 g/cm3(Predicted)

Flash point:

2℃

storage temp. 

-20°C

solubility 

Soluble in DMSO, ethanol or methanol

pka

4.17±0.10(Predicted)

form 

Solid

color 

White to off-white

BRN 

4198042

Stability:

Light Sensitive

Safety Information

Hazard Codes 

T,N,Xn,F

Risk Statements 

25-37/38-41-50/53-36-20/21/22-11

Safety Statements 

26-39-45-60-61-36/37-16

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

AG6542800

HazardClass 

6.1

MSDS

• Language:English Provider:SigmaAldrich

2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID Usage And Synthesis

Description

4-hydroxy Diclofenac is a CYP2C9 metabolite of the NSAID diclofenac . By inhibiting COX and subsequently suppressing PGE₂ synthesis, it demonstrates anti-inflammatory and analgesic properties.

Chemical Properties

Light Violet Solid

Uses

A metabolite of Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor

Uses

A Cytochrome P450 2C9 (CYP2C9) metabolite of diclofenac

Uses

A metabolite of Diclofenac, a nonsteroidal inflammatory compound and cyclooxygenase (COX) inhibitor.

Definition

ChEBI: An monocarboxylic acid that is the 4'-hydroxylated metabolite of diclofenac.

General Description

4′-Hydroxydiclofenac is one of the metabolites of diclofenac, a nonsteroidal anti-inflammatory drug (NSAID) used in human and veterinary medicine.

2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID(64118-84-9)Related Product Information

• 2-(2,6-Dichloroanilino) benzaldehyde
• 2-[(2,6-dichlorophenyl)amino]benzoicacid
• Oxindole
• Diclofenac sodium
• 1-(2,6-Dichlorophenyl)indolin-2-one
• (2-(2,6-DICHLOROANILINO)PHENYL) METHANOL
• 2-(2-Bromo-6-chlorophenyl)amino)-phenylacetic acid sodium salt 95%
• Diclofenac Impurity 7
• Diclofenac Impurity 16
• 2,6-DICHLORODIPHENYLAMINE
• 4-HYDROXY-2'-METHYLDIPHENYLAMINE
• Phenylacetic acid
• 1-(2,6-Dichlorophenyl)-2-indolinone
• 2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID
• 4-Amino-3-chlorophenol hydrochloride
• 2-ANILINOPHENYLACETIC ACID
• (2-(2,6-Dichloro-4-hydroxyanilino)-5-hydroxyphenyl)acetic acid
• 4Hydroxy Diclofenac-D4 (Major)