Basic information Safety Supplier Related

Cytochalasin H

Basic information Safety Supplier Related

Cytochalasin H Basic information

Product Name:
Cytochalasin H
Synonyms:
  • PASPALIN P1; KODOCYTOCHALASIN 1; CYTOCHALASIN O; NSC305222; 17-DEOXO-21-ACETYLZYGOSPORIN D
  • (11)cytochalasa-6(12),13,19-trien-1-one,21-(acetyloxy)-7,18-dihydroxy-16,18-di
  • (7s,13e,16s,18s,19e,21r)-methyl-10-phenyl
  • 19-triene-1-one
  • 21-acetoxy-7,18-dihydroxy-16,18-dimethyl-10-phenyl-(11)cytochalasa-6(12),13,
  • cytochalasinhfromphomopsissp.
  • kodocytochalasin-1
  • paspalin
CAS:
53760-19-3
MF:
C30H39NO5
MW:
493.63
Product Categories:
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Type
  • Other
  • Actin Inhibitors and ProbesCell Signaling and Neuroscience
  • Cell Signaling and Neuroscience
  • Cytoskeleton and Extracellular Matrix
  • Mold
  • Toxins and Venoms
Mol File:
53760-19-3.mol
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Cytochalasin H Chemical Properties

Melting point:
252-258 °C
Boiling point:
587°C (rough estimate)
Density 
1.1369 (rough estimate)
refractive index 
1.6310 (estimate)
storage temp. 
2-8°C
solubility 
chloroform: 10 mg/mL, clear, colorless
pka
13.88±0.70(Predicted)
form 
A lyophilisate
color 
Long needles from CHCl3/Et2O
BRN 
1632647
InChIKey
NAEWXXDGBKTIMN-QHDZSFFESA-N
LogP
4.758 (est)
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Safety Information

Hazard Codes 
T+
Risk Statements 
26/27/28-63
Safety Statements 
28-36/37-45
RIDADR 
UN 3462 6.1/PG 2
WGK Germany 
3
RTECS 
HA5306000
F 
10
HazardClass 
6.1(a)
PackingGroup 
I
Toxicity
cyt-hmn:lym 50 mg/L IJEBA6 16,430,78

MSDS

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Cytochalasin H Usage And Synthesis

Uses

Cytochalasin H is one of a family of potent mycotoxins produced by a range of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, resulting in pronounced morphogenic changes in animals and plants. In vitro, cytochalasin H exhibits antibacterial, antifungal, nematocidal and antitumour activity.

Safety Profile

Poison by intravenous and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

in vivo

Cytochalasin H (2.5 mg/kg; i.p.) can delay the growth of A549 xenograft tumors in Balb/cnu/nu mice[2].

Animal Model:male Balb/cnu/nu mice with A549 xenograft[2]
Dosage:2.5 mg/kg
Administration:intraperitoneal injection; 3 injections/week,for 80 days
Result:Attenuated tumor growth in vivo.

storage

+4°C

Cytochalasin HSupplier

Chembest Research Laboratories Limited Gold
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
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Chengdu HuaXia Chemical Reagent Co. Ltd
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400-1166-196 13458535857
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cdhxsj@163.com
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Cytochalasin H(53760-19-3)Related Product Information