4,6-DIHYDROXY-2-METHOXYPYRIMIDINE
4,6-DIHYDROXY-2-METHOXYPYRIMIDINE Basic information
- Product Name:
- 4,6-DIHYDROXY-2-METHOXYPYRIMIDINE
- Synonyms:
-
- 4,6-DIHYDROXY-2-METHOXYPYRIMIDINE
- 4(1H)-Pyrimidinone, 6-hydroxy-2-methoxy- (9CI)
- 4,6-Dihydroxy-2-MethoxypyiMidine
- 2-Methoxy-4,6-dihydroxypyriMidine
- 2-MethoxypyriMidine-4,6-diol
- 4(1H)-PyriMidinone, 6-hydroxy-2-Methoxy-
- 4(3H)-Pyrimidinone, 6-hydroxy-2-methoxy-
- 4,6-DIHYDROXY-2-METHOXYPYRIMIDINE ISO 9001：2015 REACH
- CAS:
- 1758-98-1
- MF:
- C5H6N2O3
- MW:
- 142.11
- Product Categories:
-
- PYRIMIDINE
- Heterocycle-Pyrimidine series
- Mol File:
- 1758-98-1.mol
4,6-DIHYDROXY-2-METHOXYPYRIMIDINE Chemical Properties
- Melting point:
- 193-195℃
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 4.39±0.10(Predicted)
4,6-DIHYDROXY-2-METHOXYPYRIMIDINE Usage And Synthesis
Synthesis
5329-33-9
108-59-8
1758-98-1
General procedure for the synthesis of 4,6-dihydroxy-2-methoxypyrimidines from O-methylisourea hydrochloride and dimethyl malonate: Step 1: Synthesis of 2-methoxy-pyrimidine-4,6-diols In a sealed tube, O-methylisourea hydrochloride (3.0 g, 27 mmol) and dimethyl malonate (3.1 mL, 27 mmol) were dissolved in a 30% w/v sodium methanol solution in methanol. The reaction mixture was heated to reflux for 4 h, followed by cooling to room temperature and allowed to stand overnight. The resulting white precipitate was collected by filtration and dried under vacuum to give 4.2 g (quantitative yield) of 4,6-dihydroxy-2-methoxypyrimidine. 1H NMR (DMSO-d6, 400 MHz) δ: 10.21 (br s, 1H), 4.09 (s, 1H), 3.65 (s, 3H).
References
[1] Patent: WO2007/65940, 2007, A1. Location in patent: Page/Page column 49
[2] Patent: US2012/88755, 2012, A1. Location in patent: Page/Page column 66-67
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4,6-DIHYDROXY-2-METHOXYPYRIMIDINE(1758-98-1)Related Product Information
- 4,6-DIHYDROXY-2-METHOXYPYRIMIDINE
- 4,6-DIHYDROXY-5-METHOXYPYRIMIDINE
- 5-METHOXYURACIL/2,4-DIHYDROXY-5-METHOXYPYRIMIDINE,2,4-DIHYDROXY-5-METHOXYPYRIMIDINE
- 2-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]BENZOIC ACID
- METHYL 3-FORMYLINDOLE-6-CARBOXYLATE
- 3-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]PYRIDINE-2-CARBOXYLIC ACID
- 4,6-DIHYDROXY-5-METHOXYPYRIMIDINE DISODIUM SALT
- 3-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]-N-METHYL-N-PHENYL-2-PYRIDINEMETHANAMINE
- A-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]-2,3-DIHYDRO-5-BENZOFURANACETIC ACID, ETHYL ESTER
- 3-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]-N-(4-METHOXYPHENYL)-N-METHYL-2-PYRIDINEMETHANAMINE
- 2-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]-3-METHYLBUTANOIC ACID
- 2-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]-6-METHOXYBENZOIC ACID
- 2-METHYL-4-[2-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]PHENYL]PYRIMIDINE
- 4,6-DIMETHOXY-2-[2-(PYRIMIDIN-4-YL)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHOXY]PYRIMIDINE
- 2-[2-(1,3,4-OXADIAZO-2-YL)PHENYLOXY]-4,6-DIMETHOXYPYRIMIDINE
- 2-[2-(N-METHYLPYRAZOL-3-YL)PHENYLOXY]-4,6-DIMETHOXYPYRIMIDINE
- METHYL 2-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]-6-CHLOROBENZOATE
- 2-[2-(5-METHYL-1,2,4-OXADIAZOLO-3-YL)PHENYLOXY]-4,6-DIMETHOXYPYRIMIDINE