2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE Chemical Properties

Melting point:

182-184°C

Boiling point:

244℃

Density 

1.20

Flash point:

101℃

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

form 

Solid

pka

6.22±0.25(Predicted)

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2933299090

2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE Usage And Synthesis

Synthesis

General procedure for the synthesis of 1-methyl-2-chloromethylimidazole from 1-methyl-2-hydroxymethyl-1H-imidazole: 1.8 mL of thionyl chloride was slowly added dropwise to 1.12 g of 1-methyl-2-hydroxymethyl-1H-imidazole at 0 °C. The reaction mixture was stirred at 20 °C for 18 h. Then, the temperature was raised to 70 °C to continue the reaction for 2 h. The reaction was carried out at 20 °C. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure and the target product 1-methyl-2-chloromethylimidazole was quantitatively obtained. 1H NMR data of the product (DMSO-d6, δ/ppm): 3.90 (s, 3H); 5.22 (s, 2H); 5.36 (t, 1H); 7.77 (d, 1H); 7.80 (d, 1H).

References

[1] Patent: US2007/185136, 2007, A1. Location in patent: Page/Page column 67
[2] Patent: WO2007/42545, 2007, A1. Location in patent: Page/Page column 18
[3] Journal of the Chemical Society, 1957, p. 3305
[4] Patent: US4746669, 1988, A
[5] Patent: WO2016/92326, 2016, A1. Location in patent: Paragraph 00802

2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE(19225-92-4)Related Product Information

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