Physalaemin
Physalaemin Basic information
- Product Name:
- Physalaemin
- Synonyms:
-
- FI 6422
- Physalemin(7CI,8CI,9CI)
- PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2
- PHYSALAEMIN
- PHYSALAEMIN ACOH 3H2O
- PYROGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET NH2
- PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2
- PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2 ACOH 3H2O
- CAS:
- 2507-24-6
- MF:
- C58H84N14O16S
- MW:
- 1265.44
- Product Categories:
-
- Peptide
- Mol File:
- 2507-24-6.mol
Physalaemin Chemical Properties
- storage temp.
- −20°C
- solubility
- Soluble in DMSO
- InChI
- InChI=1/C58H84N14O16S/c1-31(2)25-39(54(84)66-36(49(61)79)21-24-89-4)65-47(76)30-62-51(81)40(27-34-15-17-35(73)18-16-34)68-55(85)41(26-33-11-6-5-7-12-33)69-53(83)37(13-8-9-22-59)67-56(86)42(28-45(60)74)70-57(87)44-14-10-23-72(44)58(88)43(29-48(77)78)71-50(80)32(3)63-52(82)38-19-20-46(75)64-38/h5-7,11-12,15-18,31-32,36-44,73H,8-10,13-14,19-30,59H2,1-4H3,(H2,60,74)(H2,61,79)(H,62,81)(H,63,82)(H,64,75)(H,65,76)(H,66,84)(H,67,86)(H,68,85)(H,69,83)(H,70,87)(H,71,80)(H,77,78)/t32-,36-,37-,38-,39-,40-,41-,42-,43-,44-/s3
- InChIKey
- SHSUJLMLURFKID-PYQGFWJGNA-N
- SMILES
- [C@@H]1(C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N)CCSC)CC2C=CC(O)=CC=2)CC2C=CC=CC=2)CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCC(=O)N1 |&1:0,4,12,21,25,33,41,70,78,83,r|
MSDS
- Language:English Provider:SigmaAldrich
Physalaemin Usage And Synthesis
Description
Physalaemin is an oligopeptide that is originally derived from the skin of the South American frog Physalaemus fuscumaculatus. It belongs to the class of kinins and shares a similar chemical structure and mode of action with Substance P. It is a potent vasodilator and has hypotensive effects.
Uses
Physalaemin is a neuropeptide found in amphibians that has shown potential in the treatment of Sjogren's disease.?
Biological Activity
Physalaemin is a non-mammalian tachykinin that selectively binds with high affinity to the neurokinin-1 (NK1) receptor.
in vitro
Physalaemin (PHY), an undecapeptide with the sequence pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2, is a member of the tachykinin family of neuropeptides. PHY is very close to the mammalian tachykinin substance P (SP) in its function and chemical composition, and SP is well studied and characterized. Physalaemin is a bradykinin potentiating peptide (BPP-5a).
target
Neurokinin-1 (NK1) receptor
References
[1] Grace CR, et al. Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance. Biopolymers. 2011;96(3):252-9. DOI:10.1002/bip.21519
[2] Kobayashi J, Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):827-31. DOI:10.1248/CPB.54.827
[3] Hypotensive effect of eledoisin, physalaemin and related peptides in man DOI: 10.1007/BF00535905
[4] Physalaemin Inhibits Thyrotropin Secretion in Rats DOI: 10.1055/s-0029-1210457
[5] Action of Physalaemin on the Ionic Transport Across the Frog Skin: Archives of Physiology and Biochemistry: Vol 105, No DOI: 10.1055/s-0029-1210457
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Physalaemin(2507-24-6)Related Product Information
- [L-Lys5,L-Thr6]physalaemin
- physalaemin, Lys(5)-Thr(6)-
- physalaemin C-terminal heptapeptide
- [[(S,S)PRO-LEU(SPIRO-GAMMA-LACTAM)]9,10, TRP11]PHYSALAEMIN (1-11)
- GLY-LEU-MET-NH2
- 4-PYRROLIDIN-1-YL-BUTAN-1-OL
- AC-PHE-TYR-NH2
- SUBSTANCE P (7-11)
- Physalaemin
- N,N-DIMETHYLSUCCINAMIC ACID
- 4-OXO-4-PYRROLIDIN-1-YL-BUTYRIC ACID
- AC-MET-NH2
- pyrrolidine-1-butyric acid
- 4-(2-CARBAMOYL-PYRROLIDIN-1-YL)-4-OXO-BUTYRIC ACID