13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2 Chemical Properties

Boiling point:

542.1±40.0 °C(Predicted)

Density 

1.086±0.06 g/cm3(Predicted)

pka

4.76±0.10(Predicted)

13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2 Usage And Synthesis

Description

13,14-dihydro-15-keto Prostaglandin D₂ (13,14-dihydro-15-keto PGD₂) is a metabolite of PGD₂ which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD₂ was recently identified as a selective agonist for the CRTH2/DP₂ receptor. It also inhibits ion flux in a canine colonic mucosa preparation. In humans, 13,14-dihydro-15-keto PGD₂ is further metabolized to give 11β-hydroxy compounds which have also undergone β-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD₂ survives intact in the urine.

Uses

13,14-Dihydro-15-keto-PGD2 is a metabolite of Prostaglandin D2 (CAT# P838575) and a selective CRTh2/DP2 receptor agonist. CRTh2/DP2 receptors play crucial roles in atopic dermatitis, asthma, and other inflammatory diseases.

Definition

ChEBI: 13,14-dihydro-15-ketoprostaglandin D2 is a prostaglandins D. It has a role as a metabolite. It is functionally related to a prostaglandin D2.

13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2(59894-07-4)Related Product Information

• ALLYLCYCLOPENTANE
• CIS-5-DODECENOIC ACID
• cis-5-Eicosenoic acid
• 13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2