PHENYLBIGUANIDE
PHENYLBIGUANIDE Basic information
- Product Name:
- PHENYLBIGUANIDE
- Synonyms:
-
- phenyldiguanide
- 1-PHENYLBIGUANIDE
- N-PHENYLIMINODICARBONIMIDIC-DIAMIDE
- PHENYLBIGUANIDE
- 2-(N2-Phenylamidino)guanidine
- 1-phenyl-biguanid
- n-phenyl-n’-guanylguanidine
- p1426
- CAS:
- 102-02-3
- MF:
- C8H11N5
- MW:
- 177.21
- EINECS:
- 202-998-5
- Product Categories:
-
- AgonistsOrganic Building Blocks
- Guanidines
- Neurotransmitters
- Nitrogen Compounds
- Serotonergics
- Mol File:
- 102-02-3.mol
PHENYLBIGUANIDE Chemical Properties
- Melting point:
- 135-142 °C (lit.)
- Boiling point:
- 299.13°C (rough estimate)
- Density
- 1.2512 (rough estimate)
- refractive index
- 1.6900 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- alcohol: freely soluble
- pka
- 10.76, 2.13(at 25℃)
- form
- powder to crystal
- color
- White to Orange to Green
- Merck
- 14,7276
- InChIKey
- CUQCMXFWIMOWRP-UHFFFAOYSA-N
- CAS DataBase Reference
- 102-02-3(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
PHENYLBIGUANIDE Usage And Synthesis
Uses
1-Phenylbiguanide is a 5-hydroxytryptamine receptor agonist.
Definition
ChEBI: A member of the class of biguanides that is biguanide in which one of the terminal nitrogen atoms is substituted by a phenyl group.
General Description
1-Phenylbiguanide is a 5-hydroxytryptamine receptor agonist and increases extracellular dopamine release in rat nucleus accumbens in vivo. It serves as building block for synthesis of heterocyclic compounds.
in vivo
In anaesthetised mice, Phenylbiguanide (PBG), a drug that is known to stimulate cardiopulmonary afferent C-fibres,is injected into the right atrium of the heart and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression[3].
IC 50
5-HT3 Receptor: 3 μM (EC50)
Purification Methods
Crystallise the biguanide from water or toluene. [Beilstein 12 H 370, 12 I 236, 12 III 807.]
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PHENYLBIGUANIDE(102-02-3)Related Product Information
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- Biguanide
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- PHENYLBIGUANIDE MBT SALT 1G [R]
- PHENYLBIGUANIDE MBT SALT
- 1-(A-BENZOYLBENZYLIDENE)-5-PHENYLBIGUANIDE
- 6,6-DIMETHYL-N2-PHENYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE
- SPECS AG-690/12767754
- 3-(4-(2-CHLOROBENZYLOXY)PHENYL)-N-PHENYL-5-(PIPERIDIN-1-YL)-2,3-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A][1,3,5]TRIAZIN-7-AMINE