2,5-Difluoropyridine Chemical Properties

Melting point:

-33°C(lit.)

Boiling point:

115°C(lit.)

Density 

1.274 g/mL at 25 °C

refractive index 

1.4440

Flash point:

24℃

storage temp. 

Inert atmosphere,2-8°C

pka

-2.85±0.10(Predicted)

form 

clear liquid

color 

Colorless to Light yellow

InChI

InChI=1S/C5H3F2N/c6-4-1-2-5(7)8-3-4/h1-3H

InChIKey

XFAMUOYNXFXQTC-UHFFFAOYSA-N

SMILES

C1(F)=NC=C(F)C=C1

CAS DataBase Reference

84476-99-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

T,F,Xi,Xn

Risk Statements 

10-36/37/38-22

Safety Statements 

16-26-36/37/39-37

RIDADR 

1993

WGK Germany 

3

HazardClass 

3

HazardClass 

IRRITANT, FLAMMABLE

PackingGroup 

Ⅲ

HS Code 

29333990

Storage Class

3 - Flammable liquids

Hazard Classifications

Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3

2,5-Difluoropyridine Usage And Synthesis

Uses

2,5-Difluoropyridine is a pyridine derivative, mainly used as a pharmaceutical intermediate.

Application

2,5-Difluoropyridine is a starting material for the synthesis of many drugs, and an important intermediate for many pyridine compounds. For example, 2,5-Difluoropyridine can be used to synthesize 8-chloro-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4-hydro-quinazine-3-carboxylate, which is an important intermediate for a class of antibacterial drugs.

Chemical Properties

Colorless Transparent Liquid

Synthesis

Taking 2,5-dichloropyridine as raw material, 2,5-dibromopyridine is obtained by halogenation method, and then further through methylation, we can get the product 2,5-difluoropyridine we want. The purity of this crude product can meet the general needs of the reaction, and can be directly put into the application.

2,5-Difluoropyridine(84476-99-3)Related Product Information

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