Basic information Safety Supplier Related

NICOTINAMIDE HYDROCHLORIDE

Basic information Safety Supplier Related

NICOTINAMIDE HYDROCHLORIDE Basic information

Product Name:
NICOTINAMIDE HYDROCHLORIDE
Synonyms:
  • NIACINAMIDE HYDROCHLORIDE
  • NICOTINAMIDE HYDROCHLORIDE
  • nicotinamideHCl
  • Einecs 246-862-3
  • OBLVPWTUALCMGD-UHFFFAOYSA-N
  • NICA-001
  • Niacinamide Hydrochloride|||Nicotinic acid amide Hydrochloride|||Niacinamide Hydrochloride
  • Nicotinic acid amide Hydrochloride
CAS:
25334-23-0
MF:
C6H7ClN2O
MW:
158.59
EINECS:
246-862-3
Mol File:
25334-23-0.mol
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NICOTINAMIDE HYDROCHLORIDE Usage And Synthesis

Uses

Nicotinamide Hydrochloride is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide Hydrochloride also inhibits SIRT1. Nicotinamide Hydrochloride increases cellular NAD+, ATP, ROS levels. Nicotinamide Hydrochloride inhibits tumor growth and improves survival. Nicotinamide Hydrochloride also has anti-HBV activity[1][2][3][4].

in vivo

Nicotinamide Hydrochloride (Intraperitoneal injection, 1500 and 1800 mg/Kg, 5 days per week) inhibits tumor growth in murine metastatic melanoma model[1].
Nicotinamide Hydrochloride (Intraperitoneal injection, 1800 mg/Kg, once a day, murine metastatic melanoma model) affects IFN-γ (a key mediator of cell-mediated anti-tumor immunity), increases the plasma levels of Eotaxin and IL-5, reduces the plasma levels of IL-3, IL-12, RANTES and IL-10[1].
Nicotinamide Hydrochloride (vein injection, 0-200 mg/kg, 5 days) inhibits HBV replication in HBV-transgenic mice[3].

Animal Model:C57BL/6 mice (subcutaneous injected with B16-F10 cells)[1]
Dosage:1000, 1500, 1800 mg/Kg.
Administration:Intraperitoneal injection, 5 days per week (followed by 2-day rest) or once a day.
Result:Inhibited tumor growth at 1500 and 1800 mg/Kg, and had no effect on the body weight. Increased the frequency of IFN-γ producing cells and modulated the protein levels of cytokines and chemokines in the plasma of tumor-bearing mice.
Animal Model:HBV-transgenic mice[3]
Dosage:0-200 mg/kg
Administration:Vein injection, 5 days
Result:Reduced serum HBV DNA.

IC 50

Human Endogenous Metabolite; SIRT2: 2 μM (EC50); SIRT1: 50-180 μM (IC50)

References

[1] Francesca Scatozza, et al. Nicotinamide inhibits melanoma in vitro and in vivo. J Exp Clin Cancer Res. 2020 Oct 7;39(1):211. DOI:10.1186/s13046-020-01719-3
[2] Hwang ES, et al. Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells. Cell Mol Life Sci. 2017 Sep;74(18):3347-3362. DOI:10.1007/s00018-017-2527-8
[3] Li WY, et al. The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo. Arch Virol. 2016 Mar;161(3):621-30. DOI:10.1007/s00705-015-2712-8
[4] Zhang Y, et al. Nicotinamide promotes pancreatic differentiation through the dual inhibition of CK1 and ROCK kinases in human embryonic stem cells. Stem Cell Res Ther. 2021 Jun 25;12(1):362. DOI:10.1186/s13287-021-02426-2

NICOTINAMIDE HYDROCHLORIDESupplier

Shanghai CR Corporation Limited
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13062833949; 4006653949 4006653949
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fred.wen@crcorporation.cn
Shanghai Weishukur Medical Technology Co., LTD
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15250615384
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
DAYANG CHEM (HANGZHOU) CO.,LTD
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+86-88938639 +86-17705817739
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info@dycnchem.com
TargetMol Chemicals Inc.
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+17819995354
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marketing@targetmol.com
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