4-Benzylpyridine Chemical Properties

Melting point:

9-11 °C

Boiling point:

287 °C (lit.)

Density 

1.061 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.582(lit.)

Flash point:

239 °F

storage temp. 

Indoors

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Liquid

pka

5.75±0.10(Predicted)

color 

yellow

PH

8 (H2O, 20℃)

Water Solubility 

Soluble in ethanol, ethyl ether. Insoluble in water.

BRN 

115831

LogP

2.620

CAS DataBase Reference

2116-65-6(CAS DataBase Reference)

NIST Chemistry Reference

Pyridine, 4-(phenylmethyl)-(2116-65-6)

EPA Substance Registry System

Pyridine, 4-(phenylmethyl)- (2116-65-6)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

US2625000

TSCA 

Yes

HS Code 

29333999

Toxicity

LD50 ivn-mus: 25 mg/kg CSLNX* NX#12240orl-bwd LD50:18 mg/kg TXAPA9 21,315,72

MSDS

• Language:English Provider:4-Benzylpyridine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Benzylpyridine Usage And Synthesis

Chemical Properties

colorless or clear slightly yellow liquid. Boiling point 284-287°C, 180-181°C (4.13kPa). Relative density 1.062, refractive index 1.5785. soluble in ethanol, ether, insoluble in water.

Uses

4-Benzylpyridine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, dyes and agrochemicals.It is the key raw material for the synthesis of Ifenprodil hemitartrate.

Preparation

4-Benzylpyridine is synthesized from benzyl chloride and pyridine.

Synthesis Reference(s)

The Journal of Organic Chemistry, 27, p. 1889, 1962 DOI: 10.1021/jo01052a509

Safety Profile

Poison by ingestion andintravenous routes. A flammable material. Incompatible with oxidizers. When heated to decomposition it emitstoxic fumes of NOx.

Purification Methods

Dry it with NaOH for several days, then distil it from CaO under reduced pressure, and redistil the middle fraction. [Beilstein 20/7 V 561.]

4-Benzylpyridine(2116-65-6)Related Product Information

• 2-Chloro-5-chloromethylpyridine
• 2,4,6-Collidine
• BENZYL GLYCIDYL ETHER
• Benzyltriethylammonium chloride
• N,N-Dimethylbenzylamine
• 4-Phenylpyridine
• 4-Methylpyridine
• 2,6-Lutidine
• Benzyl chloride
• Benzyltrimethylammonium chloride
• Azamethiphos
• (-)-2-[METHYLAMINO]-1-PHENYLPROPANE
• 4-(4-PYRIDYLMETHYL)ANILINE
• 4-(4-CHLOROBENZOYL)PYRIDINE
• Phenyl(4-pyridyl)methanol
• 4-(4-Nitrobenzyl)pyridine
• Diphenyl(4-pyridyl)methanol
• 4-(4-CHLOROBENZYL)PYRIDINE