2-ACETYL-4-CYANOPHENOL Chemical Properties

Melting point:

103 °C

Boiling point:

313.5±32.0 °C(Predicted)

Density 

1.26±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

8.04±0.18(Predicted)

color 

Off-White to Pale Yellow

Safety Information

HS Code 

2926907090

2-ACETYL-4-CYANOPHENOL Usage And Synthesis

Preparation

Obtained by heating a mixture of 4-cyanophenyl acetate and aluminium chloride at 180–185° for 2 h (58%).

Synthesis

The general procedure for the synthesis of 2-acetyl-p-cyanophenol from 4-cyanophenyl acetate by Fries rearrangement reaction was as follows: phenyl acetate was heated and reacted with aluminum chloride for 3 h at 180-185 °C for Fries rearrangement. After completion of the reaction, the target product 2-acetyl-p-cyanophenol was isolated in 45% yield.

References

[1] ChemMedChem, 2013, vol. 8, # 6, p. 914 - 918
[2] Patent: US2007/117823, 2007, A1. Location in patent: Page/Page column 7
[3] Patent: WO2007/54580, 2007, A1. Location in patent: Page/Page column 15
[4] Letters in Drug Design and Discovery, 2010, vol. 7, # 6, p. 415 - 420
[5] Medicinal Chemistry Research, 2015, vol. 24, # 7, p. 3008 - 3020

2-ACETYL-4-CYANOPHENOL(35794-84-4)Related Product Information

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