beta-Cyclodextrin methyl ethers Chemical Properties

Melting point:

180-182 °C(lit.)

alpha 

+159°(25℃, c=1, H2O)

Flash point:

187 °C

storage temp. 

room temp

solubility 

H2O: soluble50mg/mL

form 

powder

color 

White to off-white

optical activity

[α]25/D +159°, c = 1 in H2O

Water Solubility 

Soluble in water

InChIKey

YZOUYRAONFXZSI-SBHWVFSVSA-N

LogP

-2.566 (est)

EPA Substance Registry System

.beta.-Cyclodextrin, methyl ethers (128446-36-6)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

TSCA 

Yes

HS Code 

35051000

MSDS

• Language:English Provider:SigmaAldrich

beta-Cyclodextrin methyl ethers Usage And Synthesis

Description

Methyl-β-cyclodextrin is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin . Methyl-β-cyclodextrin contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes. Methyl-β-cyclodextrin (5 mM) reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein. It also reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy.

Chemical Properties

White powder

Uses

substrate for laminarinase and other glucanases

Uses

Cavity size is the major determinant as to which cyclodextrin is used in complexation. The cavity diameter of β-cyclodextrins or β-glucopyranose unit compounds is well-suited for use with molecules the size of hormones, vitamins and many compounds frequently used in tissue and cell culture applications. For this reason, β-cyclodextrin is most commonly used as a complexing agent. It is used to increase the solubility of non-polar substances such as fatty acids, lipids, vitamins and cholesterol for use in cell culture applications. Methyl-β-cyclodextrin is used to remove cholesterol from cultured cells and is employed to remove lipid rafts.

Uses

Methyl-β-cyclodextrin is a cholesterol-removing agent mainly used for lipid raft disruption. It may also be used for detergent removal from protein-lipid-detergent ternary mixture to produce 2D membrane protein crystals due to its high solubility and affinity for detergents generally used in membrane protein chemistry.

General Description

Methyl-β-cyclodextrin is a small cyclic heptasaccharide.

Biochem/physiol Actions

Methyl-β-cyclodextrin participates in increasing the permeability of cells. It also plays a role in depolymerizing the actin cytoskeleton in cells. Methyl-β-cyclodextrin is involved in attracting cholesterol from the plasma. It participates in activating extracellular receptor kinase in certain cells.

beta-Cyclodextrin methyl ethers(128446-36-6)Related Product Information

• Tribenuron methyl
• Thiophanate-methyl
• gamma-Cyclodextrin
• POLY(METHYLSILSESQUIOXANE)
• 2,6-Lutidine
• CYCLODEXTRIN
• beta-Cyclodextrin hydrate
• Methyl salicylate
• Methyl acetate
• Kresoxim-methyl
• 2,6-DI-O-METHYL-BETA-CYCLODEXTRIN
• METSULFURON METHYL
• 2-Hydroxypropyl-β-cyclodextrin
• β-Cyclodextrin
• Calcium lactate
• Methyl
• METHYL BETA-D-GLUCOPYRANOSIDE
• alpha-D-Methylglucoside