Ketanserin Chemical Properties

Melting point:

227-235°C

Density 

1.280±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

solubility 

DMF: 10 mg/mL, clear, colorless

form 

Solid

pka

7.5(at 25℃)

color 

White to Off-White

Merck 

14,5296

CAS DataBase Reference

74050-98-9(CAS DataBase Reference)

Safety Information

WGK Germany 

3

RTECS 

VA1411190

HS Code 

29339900

MSDS

• Language:English Provider:Ketanserin
• Language:English Provider:SigmaAldrich

Ketanserin Usage And Synthesis

Description

Ketanserin is an antihypertensive agent with antagonist properties at both the serotonin-S2 and α1-adrenergic receptors. Its mechanism of action, while still controversial, may involve interactions at both of these loci.

Chemical Properties

Off-White Solid

Originator

Janssen (Belgium)

Uses

An antihypertensive, with affinity for multiple GPCR receptors.

Uses

receptor antagonist

Definition

ChEBI: A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.

brand name

SEREFREX

Purification Methods

It has been purified by recrystallisation from 4-methyl-3-pentanone [Peeters et al. Cryst Structure Commun 11 375 1982, Kacprowicz et al. J Chromatogr 272 417 1983, Davies et al. J Chromatogr 275 232 1983]. It is an antihypertensive.

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