2,5-Diaminopyrimidine Chemical Properties

Melting point:

200 °C

Boiling point:

401.7±37.0 °C(Predicted)

Density 

1.368±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

4.83±0.10(Predicted)

Appearance

Yellow to brown Solid

2,5-Diaminopyrimidine Usage And Synthesis

Synthesis

Synthesis of I-5: To a 1L round bottom flask was added 5-nitropyrimidin-2-amine (30 g, 214.13 mmol, 1.00 eq.), methanol (400 mL) and palladium carbon (12 g). The reaction mixture was stirred overnight at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the solid catalyst was removed by filtration. The filtrate was concentrated under reduced pressure to afford pyrimidine-2,5-diamine (20 g, 85% yield) as a light brown solid.

References

[1] Patent: US7235559, 2007, B1
[2] Patent: US2014/275119, 2014, A1. Location in patent: Paragraph 0416
[3] Journal of the American Chemical Society, 1942, vol. 64, p. 2340
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1681 - 1694
[5] Patent: WO2010/111483, 2010, A1. Location in patent: Page/Page column 90

2,5-Diaminopyrimidine(22715-27-1)Related Product Information

• Diaminomaleonitrile
• 4,4'-Methylenedianiline
• 4-Aminopyrimidine
• 2-Aminopyrimidine
• Iminodiacetic acid
• Iminodiacetonitrile
• HYDRAZINE
• 4,6-DIAMINOPYRIMIDINE
• 2,4,5-Triamino-6-chloropyrimidine hydrochloride
• 2-AMINO-4,6-DIHYDROXY-5-NITROPYRIMIDINE
• 5-Nitro-2,4,6-triaminopyrimidine
• Calcium folinate
• 2,4-DIAMINO-6-HYDROXY-5-NITROSOPYRIMIDINE
• 4-Amino-2-dimethylamino-6-hydroxy-5-nitrosopyrimidine
• 2-Amino-5-nitropyrimidine
• 2,5-Diamino-4,6-dihydropyrimidine hemisulfate salt
• Pyrimidinetetraamine/sulfuric acid,(1:x)
• 5-METHYLTETRAHYDROFOLIC ACID DISODIUM SALT