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Cloperastine hydrochloride

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Cloperastine hydrochloride Basic information

Product Name:
Cloperastine hydrochloride
Synonyms:
  • 1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-piperidinhydrochloride
  • 1-(2-(p-cloro-alpha-fenilbenzilossi)etil)piperidinacloridrato
  • 2-piperidinoethylp-chlorobenzhydryletherhydrochloride
  • cloperastinacloridrato
  • ht11
  • hustazol
  • 4-CHLOROBENZHYDRYL 2-[1-PIPERIDYL]-ETHYL ETHER HYDROCHLORIDE
  • CHLOPERASTINE HYDROCHLORIDE
CAS:
14984-68-0
MF:
C20H25Cl2NO
MW:
366.32
EINECS:
239-067-8
Mol File:
14984-68-0.mol
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Cloperastine hydrochloride Chemical Properties

Melting point:
147.9°
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
Merck 
14,2395
InChI
InChI=1S/C20H24ClNO.ClH/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22;/h1,3-4,7-12,20H,2,5-6,13-16H2;1H
InChIKey
UNPLRYRWJLTVAE-UHFFFAOYSA-N
SMILES
C(OCCN1CCCCC1)(C1C=CC=CC=1)C1=CC=C(Cl)C=C1.Cl
CAS DataBase Reference
14984-68-0(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
TM6491500
HS Code 
2933.39.9200

MSDS

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Cloperastine hydrochloride Usage And Synthesis

Uses

Antitussive;'Histamine antagonist

Uses

Cloperastine Hydrochloride is an anti-tussive drug as an over-the-counter cold medicine.

Definition

ChEBI: Cloperastine hydrochloride is a diarylmethane.

in vivo

In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic? action potential (MAP) duration without affecting PR interval or QRS width[1].
? Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively[2].

Cloperastine hydrochlorideSupplier

Liaoyuan Baikang Pharmaceutical Co., Ltd. Gold
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
Email
info@hanhongsci.com
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