20-HETE Chemical Properties

Boiling point:

482.0±33.0 °C(Predicted)

Density 

0.985±0.06 g/cm3(Predicted)

Flash point:

14℃

storage temp. 

-20°C

solubility 

0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml

pka

4.75±0.10(Predicted)

form 

Powder

Safety Information

Hazard Codes 

F,Xi

Risk Statements 

11-36/37/38

Safety Statements 

16-26-36

RIDADR 

UN 1170 3/PG 2

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

20-HETE Usage And Synthesis

Uses

20-HETE is a cytochrome P450 (CYP450) metabolite that may play an autacoid role in cerebral and renal vasculature.

Definition

ChEBI: A HETE that consists of arachidonic acid bearing a hydroxy substituent at position 20.

Biochem/physiol Actions

20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid (20-HETE) is an arachidonic acid metabolite via cytochrome P4504A, that is an activator of the Ras/MAP (microtubule-associated protein) pathway. 20-HETE acid is a predominant arachidonic acid present in the kidney. It is involved in the regulation of sodium, potassium and chloride transport in the renal tubules. 20-HETE is often excreted in urine in the form of glucuronide conjugate and sometimes as free acids. Increased urine 20-HETE is observed during pregnancy in rats.

20-HETE(79551-86-3)Related Product Information

• ARACHIDONYL ALCOHOL APPROX 99
• 20-HETE-D6
• 20-HETE
• Arachidonic acid