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Calcium dobesilate

Basic information Safety Supplier Related

Calcium dobesilate Basic information

Product Name:
Calcium dobesilate
Synonyms:
  • CALCIUM DOBESILATE
  • Calcium Dobesilate Mnohydrate
  • CALIUM DOBESILATE MONOHYDRATE
  • CALCIUM DOBESILATE 1-HYDRATE
  • 2,5-Dihydroxybenzenesulfonic acid, calcium salt
  • 2,5-dihydroxy-benzenesulfonic aci calcium salt
  • dexium
  • doxium
CAS:
20123-80-2
MF:
2C6H5O5S.Ca
MW:
418.41
EINECS:
243-531-5
Product Categories:
  • API
Mol File:
20123-80-2.mol
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Calcium dobesilate Chemical Properties

Melting point:
>300° (dec)
storage temp. 
room temp
solubility 
H2O: soluble15mg/mL, clear
form 
powder
color 
white to beige
InChIKey
QGNBTYAQAPLTMX-UHFFFAOYSA-L
CAS DataBase Reference
20123-80-2(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
HazardClass 
IRRITANT
Toxicity
LD50 in mice: 700 mg/kg (Esteve-Subirana)

MSDS

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Calcium dobesilate Usage And Synthesis

Chemical Properties

White or almost white, hygroscopic powder.

Originator

Doxium,Carrion,France,1971

Uses

Vasotropic/ Venous Disorders

Manufacturing Process

To an ether solution of 108 grams 1,4-benzoquinone, maintained below 0°C, one adds an also very cold solution of 102 grams of pure calcium bisulfite as a 50% solution in distilled water. The addition is made carefully so as to maintain a very low temperature (0° to 4°C) in the vessel, and under stirring so as to mix the water and ether phase.
At the end of the addition, an almost colorless ether layer swims on the surface of the strongly colored water layer. After removal of the ether layer, the water layer is concentrated to dryness under vacuum and a stream of an inert gas. An earthy precipitate is formed, which after recrystallization yields 100 grams of hydroquinone calcium sulfonate, which decomposes without melting above 250°C.
The product consists of very small crystals having a powdery aspect and a pink color which deepens on contact with air. This product is very soluble in water and alcohol, and insoluble in ether.

Therapeutic Function

Vasodilator

Calcium dobesilateSupplier

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