Calcium dobesilate Chemical Properties

Melting point:

>300° (dec)

storage temp. 

room temp

solubility 

H2O: soluble15mg/mL, clear

form 

powder

color 

white to beige

InChIKey

QGNBTYAQAPLTMX-UHFFFAOYSA-L

CAS DataBase Reference

20123-80-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

HazardClass 

IRRITANT

Toxicity

LD50 in mice: 700 mg/kg (Esteve-Subirana)

MSDS

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Calcium dobesilate Usage And Synthesis

Chemical Properties

White or almost white, hygroscopic powder.

Originator

Doxium,Carrion,France,1971

Uses

Vasotropic/ Venous Disorders

Manufacturing Process

To an ether solution of 108 grams 1,4-benzoquinone, maintained below 0°C, one adds an also very cold solution of 102 grams of pure calcium bisulfite as a 50% solution in distilled water. The addition is made carefully so as to maintain a very low temperature (0° to 4°C) in the vessel, and under stirring so as to mix the water and ether phase.
At the end of the addition, an almost colorless ether layer swims on the surface of the strongly colored water layer. After removal of the ether layer, the water layer is concentrated to dryness under vacuum and a stream of an inert gas. An earthy precipitate is formed, which after recrystallization yields 100 grams of hydroquinone calcium sulfonate, which decomposes without melting above 250°C.
The product consists of very small crystals having a powdery aspect and a pink color which deepens on contact with air. This product is very soluble in water and alcohol, and insoluble in ether.

Therapeutic Function

Vasodilator

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