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2-Methylpropanedioic acid

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2-Methylpropanedioic acid Basic information

Product Name:
2-Methylpropanedioic acid
Synonyms:
  • 1,1-Ethanedicarboxylic acid
  • 1,1-ethanedicarboxylicacid
  • 2-Methylmalonic acid
  • 2-methylmalonicacid
  • Isosuccinic acid
  • isosuccinicacid
  • Malonic acid, methyl-
  • methyl-malonicaci
CAS:
516-05-2
MF:
C4H6O4
MW:
118.09
EINECS:
208-219-5
Product Categories:
  • Building Blocks
  • C1 to C5
  • Carbonyl Compounds
  • Carboxylic Acids
  • Chemical Synthesis
  • Organic Building Blocks
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • API intermediates
  • Aliphatics
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
Mol File:
516-05-2.mol
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2-Methylpropanedioic acid Chemical Properties

Melting point:
128-130 °C (lit.)
Boiling point:
272.71°C (rough estimate)
Density 
1.45
refractive index 
1.4304 (estimate)
Flash point:
2℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Crystalline Powder
pka
3.07, 5.76(at 25℃)
color 
White
Specific Gravity
1.455
PH
3.23(1 mM solution);2.6(10 mM solution);2.05(100 mM solution)
Water Solubility 
soluble
BRN 
1756084
CAS DataBase Reference
516-05-2(CAS DataBase Reference)
NIST Chemistry Reference
Methylmalonic acid(516-05-2)
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Safety Information

Hazard Codes 
Xi,Xn,F
Risk Statements 
36/37/38-36-20/21/22-11
Safety Statements 
26-36/37-16
RIDADR 
UN 1648 3 / PGII
WGK Germany 
3
RTECS 
OO1400000
HS Code 
29171900

MSDS

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2-Methylpropanedioic acid Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

Methylmalonic acid can be used as a substrate in:

  • Esterification reactions by various catalysts.
  • Synthesis of pyrimidinium betaines with formamidine.
  • Synthesis of malonic acid half thioester (MAHT).

Uses

2-Methylpropanedioic acid binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.

Definition

ChEBI: Methylmalonic acid is a dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group. It has a role as a human metabolite. It is functionally related to a malonic acid. It is a conjugate acid of a methylmalonate(1-).

Biological Functions

Methylmalonic acid is capable of diffusing out of cells in which it is being produced, so it may be detected in excess in the blood, CSF, and urine of patients with these various forms of the disease.

General Description

Methylmalonic acid is an indicator of vitamin B12 deficiency and methylmalonic acidemia. This Certified Spiking Solution? is suitable for use in preparation of calibrators or controls in clinical and diagnostic testing using GC/MS or LC/MS.

storage

Store at RT

Purification Methods

The acid crystallises as the hydrate from water. [Beilstein 2 IV 1932.]

2-Methylpropanedioic acid Preparation Products And Raw materials

Preparation Products

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