2-Methylpropanedioic acid
2-Methylpropanedioic acid Basic information
- Product Name:
- 2-Methylpropanedioic acid
- Synonyms:
-
- 1,1-Ethanedicarboxylic acid
- 1,1-ethanedicarboxylicacid
- 2-Methylmalonic acid
- 2-methylmalonicacid
- Isosuccinic acid
- isosuccinicacid
- Malonic acid, methyl-
- methyl-malonicaci
- CAS:
- 516-05-2
- MF:
- C4H6O4
- MW:
- 118.09
- EINECS:
- 208-219-5
- Product Categories:
-
- Building Blocks
- C1 to C5
- Carbonyl Compounds
- Carboxylic Acids
- Chemical Synthesis
- Organic Building Blocks
- Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
- API intermediates
- Aliphatics
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- Mol File:
- 516-05-2.mol
2-Methylpropanedioic acid Chemical Properties
- Melting point:
- 128-130 °C (lit.)
- Boiling point:
- 272.71°C (rough estimate)
- Density
- 1.45
- refractive index
- 1.4304 (estimate)
- Flash point:
- 2℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Crystalline Powder
- pka
- 3.07, 5.76(at 25℃)
- color
- White
- Specific Gravity
- 1.455
- PH
- 3.23(1 mM solution);2.6(10 mM solution);2.05(100 mM solution)
- Water Solubility
- soluble
- BRN
- 1756084
- CAS DataBase Reference
- 516-05-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Methylmalonic acid(516-05-2)
Safety Information
- Hazard Codes
- Xi,Xn,F
- Risk Statements
- 36/37/38-36-20/21/22-11
- Safety Statements
- 26-36/37-16
- RIDADR
- UN 1648 3 / PGII
- WGK Germany
- 3
- RTECS
- OO1400000
- HS Code
- 29171900
MSDS
- Language:English Provider:2-Methylpropanedioic acid
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
2-Methylpropanedioic acid Usage And Synthesis
Chemical Properties
white crystalline powder
Uses
Methylmalonic acid can be used as a substrate in:
- Esterification reactions by various catalysts.
- Synthesis of pyrimidinium betaines with formamidine.
- Synthesis of malonic acid half thioester (MAHT).
Uses
2-Methylpropanedioic acid binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.
Definition
ChEBI: Methylmalonic acid is a dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group. It has a role as a human metabolite. It is functionally related to a malonic acid. It is a conjugate acid of a methylmalonate(1-).
Biological Functions
Methylmalonic acid is capable of diffusing out of cells in which it is being produced, so it may be detected in excess in the blood, CSF, and urine of patients with these various forms of the disease.
General Description
Methylmalonic acid is an indicator of vitamin B12 deficiency and methylmalonic acidemia. This Certified Spiking Solution? is suitable for use in preparation of calibrators or controls in clinical and diagnostic testing using GC/MS or LC/MS.
storage
Store at RT
Purification Methods
The acid crystallises as the hydrate from water. [Beilstein 2 IV 1932.]
2-Methylpropanedioic acid Preparation Products And Raw materials
Preparation Products
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