2-Methylpropanedioic acid Chemical Properties

Melting point:

128-130 °C (lit.)

Boiling point:

272.71°C (rough estimate)

Density 

1.45

refractive index 

1.4304 (estimate)

Flash point:

2℃

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Crystalline Powder

pka

3.07, 5.76(at 25℃)

color 

White

Specific Gravity

1.455

PH

3.23(1 mM solution);2.6(10 mM solution);2.05(100 mM solution)

Water Solubility 

soluble

BRN 

1756084

CAS DataBase Reference

516-05-2(CAS DataBase Reference)

NIST Chemistry Reference

Methylmalonic acid(516-05-2)

Safety Information

Hazard Codes 

Xi,Xn,F

Risk Statements 

36/37/38-36-20/21/22-11

Safety Statements 

26-36/37-16

RIDADR 

UN 1648 3 / PGII

WGK Germany 

3

RTECS 

OO1400000

HS Code 

29171900

MSDS

• Language:English Provider:2-Methylpropanedioic acid
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

2-Methylpropanedioic acid Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

Methylmalonic acid can be used as a substrate in:

• Esterification reactions by various catalysts.
• Synthesis of pyrimidinium betaines with formamidine.
• Synthesis of malonic acid half thioester (MAHT).

Uses

2-Methylpropanedioic acid binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.

Definition

ChEBI: Methylmalonic acid is a dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group. It has a role as a human metabolite. It is functionally related to a malonic acid. It is a conjugate acid of a methylmalonate(1-).

Biological Functions

Methylmalonic acid is capable of diffusing out of cells in which it is being produced, so it may be detected in excess in the blood, CSF, and urine of patients with these various forms of the disease.

General Description

Methylmalonic acid is an indicator of vitamin B₁₂ deficiency and methylmalonic acidemia. This Certified Spiking Solution^? is suitable for use in preparation of calibrators or controls in clinical and diagnostic testing using GC/MS or LC/MS.

storage

Store at RT

Purification Methods

The acid crystallises as the hydrate from water. [Beilstein 2 IV 1932.]

2-Methylpropanedioic acid(516-05-2)Related Product Information

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