Manidipine hydrochloride Chemical Properties

Melting point:

157-163°; mp 174-180°; mp 167-170°

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Soluble in DMSO (>25 mg/ml)

form 

solid

color 

White

Water Solubility 

Soluble in DMSO. Slightly soluble in water and ethanol /n

Merck 

14,5743

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

InChIKey

UFIXGLLGFBWKAV-UHFFFAOYSA-N

SMILES

C1(C)NC(C)=C(C(OCCN2CCN(C(C3=CC=CC=C3)C3=CC=CC=C3)CC2)=O)C(C2=CC=CC([N+]([O-])=O)=C2)C=1C(OC)=O.[H]Cl

CAS DataBase Reference

89226-75-5(CAS DataBase Reference)

Safety Information

RIDADR 

UN 2811 6.1/PG III

RTECS 

US7975300

HS Code 

2933.59.8000

HazardClass 

6.1

PackingGroup 

III

Toxicity

LD50 in male, female mice, male, female rats (mg/kg): 387, 340, 222, 199 s.c.; 62.2, 68.0, 66.5, 48.8 i.p.; 190, 171, 247, 156 orally (Chiba)

Manidipine hydrochloride Usage And Synthesis

Description

Manidipine (89226-75-5) is a clinically useful antihypertensive.1,2 It is an inhibitor of L- and T-type calcium channels with high selectivity for vasculature.? Manidipine has recently been found to be an inhibitor (IC50 = 4.8 μM) of the SARS-CoV-2 main protease, 3CLpro.3 It also acts as an early entry inhibitor of human cytomegalovirus (EC50 = 3.57 μM) via inhibition of the Immediate-Early 2 (IE2) protein.4

Uses

aldosterone antagonist

Uses

Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties.

Definition

ChEBI: Manidipine dihydrochloride is a diarylmethane.

References

Kakihana et al. (1988), Antihypertensive effect of CV-4093·2HCl, a new calcium antagonist, in three rat models of hypertension; Jpn. J. Pharmacol., 48 223 McKeage (2004), Manidipine: a review of its use in the management of hypertension; Drugs, 64 1923 Ghahremanpour et al. (2020), Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2; ACS Med. Chem. Lett., 11 2526 Mercorelli et al. (2018), Repurposing the clinically approved calcium antagonist manidipine dihydrochloride as a new early entry inhibitor of human cytomegalovirus targeting the Immediate-Early 2 (IE2) protein; Antiviral Res., 150 130

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